*,:before,:after{box-sizing:border-box}html{-moz-text-size-adjust:100%;text-size-adjust:100%;hanging-punctuation:first last}body{min-block-size:100vh;text-rendering:optimizeLegibility;-webkit-font-smoothing:antialiased;margin:0}h1,h2,h3,h4,h5,h6,p,figure,blockquote,dl,dd,ol,ul{margin:0}ul[role=list],ol[role=list]{padding:0;list-style:none}img,svg,video{block-size:auto;max-inline-size:100%}svg{overflow:visible}input,button,textarea,select{font:inherit;color:inherit}button{cursor:pointer}table{border-collapse:collapse}a{color:inherit}abbr[title]{cursor:help;-webkit-text-decoration:underline dotted;text-decoration:underline dotted}[hidden]{display:none!important}:target{scroll-margin-block-start:5rem}.visually-hidden{clip-path:inset(50%);white-space:nowrap;border:0;block-size:1px;inline-size:1px;margin:-1px;padding:0;overflow:hidden;position:absolute!important}.skip-link{z-index:100;padding:.75rem 1rem;position:absolute;inset-block-start:-10rem;inset-inline-start:1rem}.skip-link:focus{inset-block-start:1rem}.site-main:focus{outline:none}:focus-visible{outline-offset:2px;outline:3px solid}@media (prefers-reduced-motion:reduce){*,:before,:after{scroll-behavior:auto!important;transition-duration:.01ms!important;animation-duration:.01ms!important;animation-iteration-count:1!important}}@media (forced-colors:active){.claim-badge,.status-badge,.level-badge,.compound-badge{border:1px solid canvastext}}[dir=rtl] .icon--dir{transform:scaleX(-1)}.seq,.qty,.ref__doi,.seq-beads{direction:ltr;unicode-bidi:isolate}bdi{unicode-bidi:isolate}time{unicode-bidi:plaintext}.seq{overflow-wrap:anywhere}.banner--pseudo{display:none}html[data-pseudo=rtl] .banner--pseudo{display:block}.glossary-defs{display:none}.term-tip{z-index:60;position:absolute}.table-scroll{max-inline-size:100%;position:relative;overflow-x:auto}.primary-nav__list,.sequence__visual,.diagram__art{position:relative}.table-scroll:focus-visible{outline-offset:4px}.prose,.doc,.site-footer{overflow-wrap:break-word}.ref__link,.ref__url{overflow-wrap:anywhere}:root:not(.js) .scheme-toggle{display:none!important}:root.js :is([data-news-filters],[data-timeline-filters])[hidden]{display:flex!important}.disclosure{position:relative}.disclosure__summary{cursor:pointer;list-style:none}.disclosure__summary::-webkit-details-marker{display:none}.site-tools{display:contents}.utility-nav .site-tools__open,.site-tools__head,.scheme-toggle__text{display:none}.site-tools__open,.site-tools__close{cursor:pointer;font:inherit}.utility-nav__alert{white-space:nowrap}@supports selector(:popover-open){@media (max-width:59.99rem){.utility-nav .site-tools__open{align-items:center;display:inline-flex}.site-tools:not(:popover-open){display:none}}.site-tools:popover-open{overscroll-behavior:contain;flex-direction:column;align-items:stretch;block-size:auto;max-block-size:100dvh;inline-size:auto;margin:0;display:flex;position:fixed;inset:0 0 auto;overflow:auto}.site-tools:popover-open .site-tools__head{justify-content:space-between;align-items:center;display:flex}.site-tools:popover-open :is(.utility-nav__text,.lang-switch__label){clip-path:none;white-space:normal;block-size:auto;inline-size:auto;margin:0;overflow:visible;position:static!important}.site-tools:popover-open .lang-switch__code{display:none}.site-tools:popover-open .scheme-toggle__text{display:inline}.site-tools:popover-open .disclosure__panel{min-inline-size:0;box-shadow:none;position:static}}@media (min-width:64rem){.doc>*{order:4}.doc>:is(.notice--fallback,.notice--translation,.opinion-flag,.doc-header){order:0}.doc>.hero{order:1;align-self:start}.doc>.doc-review{order:2}.doc>.fact-sheet{order:3}}@media print{.site-header,.site-footer,.toc,.skip-link,.site-banners,.scheme-toggle{display:none!important}a[href^=http]:after{content:" (" attr(href)")";font-size:.8em}}@font-face{font-family:Outfit;font-style:normal;font-weight:100 900;font-display:optional;src:url(../fonts/outfit-latin-ext-wght-normal.woff2)format("woff2");unicode-range:U+100-2BA,U+2BD-2C5,U+2C7-2CC,U+2CE-2D7,U+2DD-2FF,U+304,U+308,U+329,U+1D00-1DBF,U+1E00-1E9F,U+1EF2-1EFF,U+2020,U+20A0-20AB,U+20AD-20C0,U+2113,U+2C60-2C7F,U+A720-A7FF}@font-face{font-family:Outfit;font-style:normal;font-weight:100 900;font-display:optional;src:url(../fonts/outfit-latin-wght-normal.woff2)format("woff2");unicode-range:U+??,U+131,U+152-153,U+2BB-2BC,U+2C6,U+2DA,U+2DC,U+304,U+308,U+329,U+2000-206F,U+20AC,U+2122,U+2191,U+2193,U+2212,U+2215,U+FEFF,U+FFFD}@font-face{font-family:JetBrains Mono;font-style:normal;font-weight:100 800;font-display:optional;src:url(../fonts/jetbrains-mono-latin-ext-wght-normal.woff2)format("woff2");unicode-range:U+100-2BA,U+2BD-2C5,U+2C7-2CC,U+2CE-2D7,U+2DD-2FF,U+304,U+308,U+329,U+1D00-1DBF,U+1E00-1E9F,U+1EF2-1EFF,U+2020,U+20A0-20AB,U+20AD-20C0,U+2113,U+2C60-2C7F,U+A720-A7FF}@font-face{font-family:JetBrains Mono;font-style:normal;font-weight:100 800;font-display:optional;src:url(../fonts/jetbrains-mono-latin-wght-normal.woff2)format("woff2");unicode-range:U+??,U+131,U+152-153,U+2BB-2BC,U+2C6,U+2DA,U+2DC,U+304,U+308,U+329,U+2000-206F,U+20AC,U+2122,U+2191,U+2193,U+2212,U+2215,U+FEFF,U+FFFD}@font-face{font-family:Noto Sans Arabic;font-style:normal;font-weight:100 900;font-display:optional;src:url(../fonts/noto-sans-arabic-arabic-wght-normal.woff2)format("woff2");unicode-range:U+6??,U+750-77F,U+870-88E,U+890-891,U+897-8E1,U+8E3-8FF,U+200C-200E,U+2010-2011,U+204F,U+2E41,U+FB50-FDFF,U+FE70-FE74,U+FE76-FEFC,U+102E0-102FB,U+10E60-10E7E,U+10EC2-10EC4,U+10EFC-10EFF,U+1EE00-1EE03,U+1EE05-1EE1F,U+1EE21-1EE22,U+1EE24,U+1EE27,U+1EE29-1EE32,U+1EE34-1EE37,U+1EE39,U+1EE3B,U+1EE42,U+1EE47,U+1EE49,U+1EE4B,U+1EE4D-1EE4F,U+1EE51-1EE52,U+1EE54,U+1EE57,U+1EE59,U+1EE5B,U+1EE5D,U+1EE5F,U+1EE61-1EE62,U+1EE64,U+1EE67-1EE6A,U+1EE6C-1EE72,U+1EE74-1EE77,U+1EE79-1EE7C,U+1EE7E,U+1EE80-1EE89,U+1EE8B-1EE9B,U+1EEA1-1EEA3,U+1EEA5-1EEA9,U+1EEAB-1EEBB,U+1EEF0-1EEF1}:root{--lightningcss-light:initial;--lightningcss-dark: ;color-scheme:light;--ground:#f6f8fb;--surface:#fff;--surface-2:#eef2f7;--line:#d7dee8;--line-strong:#7d8a9c;--text:#0b1220;--text-2:#344256;--text-3:#556275;--cyan:#00727c;--cyan-text:#005a63;--cyan-ink:#fff;--cyan-soft:#00727c1a;--amber:#8f5300;--amber-text:#764400;--amber-ink:#fff;--amber-soft:#8f53001a;--link:#2b3bb0;--alert:#991436;--alert-ink:#fff;--alert-tint:#fbeef1;--focus:#2b3bb0;--shadow-raised:0 10px 28px #0b122024;--backdrop:#0b122066;--res-hydrophobic:#4b5be0;--res-aromatic:#8d5ad8;--res-polar:#1f9a6a;--res-positive:#cc3d7a;--res-negative:#d4483a;--res-special:#6b7686;--res-nonstandard:#0b1220;--font-sans:"Outfit",ui-sans-serif,system-ui,-apple-system,"Segoe UI",Roboto,Arial,"Noto Sans Arabic",sans-serif;--font-mono:"JetBrains Mono",ui-monospace,"SFMono-Regular",Menlo,Consolas,monospace;--s--2:.875rem;--s--1:.9375rem;--s-0:1.1875rem;--s-1:1.3125rem;--s-2:clamp(1.375rem,1.25rem + .5vw,1.625rem);--s-3:clamp(1.5rem,1.3rem + .75vw,1.875rem);--s-4:clamp(2.125rem,1.6rem + 2.2vw,3.25rem);--lh:1.65;--measure:42rem;--wide:74rem;--radius:8px;--radius-sm:6px;--radius-pill:999px;--pad:clamp(1.1rem,5vw,3rem);--space-1:.25rem;--space-2:.5rem;--space-3:.75rem;--space-4:1rem;--space-5:1.5rem;--space-6:2.5rem;--space-7:2.75rem;--space-8:3.75rem;--spring:cubic-bezier(.34,1.56,.64,1);--ease:cubic-bezier(.22,1,.36,1)}:root[data-scheme=dark],.dark-island{--lightningcss-light: ;--lightningcss-dark:initial;color-scheme:dark;--ground:#0a0e14;--surface:#0f151e;--surface-2:#151d29;--line:#233042;--line-strong:#5d6e86;--text:#e6edf3;--text-2:#b4c0cf;--text-3:#8795a8;--cyan:#5ec4d2;--cyan-text:#5ec4d2;--cyan-ink:#04161a;--cyan-soft:#5ec4d224;--amber:#e8b15f;--amber-text:#e8b15f;--amber-ink:#1d1203;--amber-soft:#e8b15f24;--link:#a5b4ff;--alert:#f78c80;--alert-ink:#0a0e14;--alert-tint:#2a1416;--focus:#a5b4ff;--shadow-raised:0 16px 36px #00000080;--backdrop:#04070c99;--res-hydrophobic:#7c8cff;--res-aromatic:#c49bff;--res-polar:#7ee2b8;--res-positive:#ff8fc0;--res-negative:#ff9a8a;--res-special:#9aa6b6;--res-nonstandard:#f2f5f8}.dark-island{color:var(--text)}@media (prefers-color-scheme:dark){:root:not([data-scheme=light]){--lightningcss-light: ;--lightningcss-dark:initial;color-scheme:dark;--ground:#0a0e14;--surface:#0f151e;--surface-2:#151d29;--line:#233042;--line-strong:#5d6e86;--text:#e6edf3;--text-2:#b4c0cf;--text-3:#8795a8;--cyan:#5ec4d2;--cyan-text:#5ec4d2;--cyan-ink:#04161a;--cyan-soft:#5ec4d224;--amber:#e8b15f;--amber-text:#e8b15f;--amber-ink:#1d1203;--amber-soft:#e8b15f24;--link:#a5b4ff;--alert:#f78c80;--alert-ink:#0a0e14;--alert-tint:#2a1416;--focus:#a5b4ff;--shadow-raised:0 16px 36px #00000080;--backdrop:#04070c99;--res-hydrophobic:#7c8cff;--res-aromatic:#c49bff;--res-polar:#7ee2b8;--res-positive:#ff8fc0;--res-negative:#ff9a8a;--res-special:#9aa6b6;--res-nonstandard:#f2f5f8}}html{background:var(--ground);color:var(--text);font-family:var(--font-sans);line-height:var(--lh);font-feature-settings:"kern","liga"}body{background:var(--ground);font-size:var(--s-0)}:lang(ar){font-family:"Noto Sans Arabic",var(--font-sans)}a{color:var(--link);text-underline-offset:.2em;transition:color .2s var(--ease);text-decoration-thickness:1px}a:hover{text-decoration-thickness:2px}:focus-visible{outline:2px solid var(--focus);outline-offset:3px;border-radius:4px}::selection{background:var(--cyan);color:var(--cyan-ink)}.skip-link{background:var(--text);color:var(--ground);border-radius:var(--radius-sm);font-weight:600;text-decoration:none}.banner{padding:var(--space-2)var(--pad);font-size:var(--s--1);background:var(--surface-2);color:var(--text-2);border-block-end:1px solid var(--line);margin:0}.site-header{background:var(--ground);border-block-end:1px solid var(--line);position:relative}.site-header__inner{justify-content:space-between;align-items:center;gap:var(--space-3)var(--space-5);max-inline-size:calc(var(--wide) + 2*var(--pad));padding:var(--space-4)var(--pad)var(--space-2);flex-wrap:wrap;margin-inline:auto;display:flex}.brand{color:var(--text);font-weight:600;font-size:var(--s-1);letter-spacing:-.02em;align-items:center;gap:.6rem;text-decoration:none;display:inline-flex}.brand-mark{block-size:2rem;inline-size:2rem}.brand-mark__bond{stroke:var(--line-strong);stroke-width:2px}.brand-mark__res{fill:var(--res-hydrophobic)}.brand-mark__res--accent{fill:var(--cyan)}.utility-nav{align-items:center;gap:var(--space-2);font-size:var(--s--1);flex-wrap:wrap;display:flex}.utility-nav__alert,.utility-nav__search,.site-tools__open{border-radius:var(--radius);min-block-size:2.5rem;color:var(--text);background:var(--surface);border:1px solid var(--line);transition:border-color .2s var(--ease);align-items:center;gap:.4em;padding-inline:.85rem;text-decoration:none;display:inline-flex}:is(.utility-nav__alert,.utility-nav__search,.site-tools__open):hover{border-color:var(--line-strong)}.utility-nav__alert{font-weight:600}.utility-nav__alert .icon{color:var(--alert)}.utility-nav a[aria-current]{border-color:var(--text)}.utility-nav .icon{block-size:1.05em;inline-size:1.05em}.disclosure__summary{border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);min-block-size:2.5rem;font-size:var(--s--1);align-items:center;gap:.4em;padding-inline:.85rem;display:inline-flex}.disclosure__summary .icon{block-size:1.05em;inline-size:1.05em}.disclosure[open]>.disclosure__summary{border-color:var(--text)}.disclosure__panel{z-index:50;min-inline-size:15rem;padding:var(--space-2);background:var(--surface);border:1px solid var(--line);border-radius:var(--radius);box-shadow:var(--shadow-raised);position:absolute;inset-block-start:calc(100% + 8px);inset-inline-end:0}.disclosure__panel a{border-radius:var(--radius-sm);color:var(--text);font-size:var(--s--1);padding:.55rem .8rem;text-decoration:none;display:block}.disclosure__panel a:hover{background:var(--surface-2)}.disclosure__panel a[aria-current]{background:var(--cyan-soft);color:var(--text)}.lang-switch__note{color:var(--text-3);font-size:var(--s--2);display:block}.scheme-toggle{border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);block-size:2.5rem;inline-size:2.5rem;color:var(--text);place-items:center;padding:0;display:inline-grid}.scheme-toggle .icon{block-size:1.1rem;inline-size:1.1rem}.scheme-toggle__dark,:root[data-scheme=dark] .scheme-toggle__light{display:none}:root[data-scheme=dark] .scheme-toggle__dark{display:block}@media (prefers-color-scheme:dark){:root:not([data-scheme=light]) .scheme-toggle__light{display:none}:root:not([data-scheme=light]) .scheme-toggle__dark{display:block}}.primary-nav{--nav-pad:.75rem;max-inline-size:calc(var(--wide) + 2*var(--pad));padding-inline:var(--pad);margin-inline:auto}.primary-nav__list{gap:var(--space-1);margin-inline:calc(-1*var(--nav-pad));padding-block:var(--space-1)var(--space-2);flex-wrap:wrap;display:flex}.primary-nav__item a{white-space:nowrap;padding:.4rem var(--nav-pad);border-radius:var(--radius);color:var(--text-2);font-size:var(--s--1);transition:background .2s var(--ease),color .2s var(--ease);font-weight:500;text-decoration:none;display:block}.primary-nav__item a:hover{color:var(--text);background:var(--surface)}.primary-nav__item a[aria-current]{color:var(--text);background:var(--surface-2);box-shadow:inset 0 0 0 1px var(--line);font-weight:600}.site-body{padding-inline:var(--pad)}.breadcrumbs{max-inline-size:var(--wide);padding-block:var(--space-4)0;font-size:var(--s--1);margin-inline:auto}.breadcrumbs__list{flex-wrap:wrap;align-items:center;gap:.25rem .5rem;display:flex}.breadcrumbs__item{color:var(--text-3);align-items:center;gap:.5rem;display:inline-flex}.breadcrumbs a{color:var(--text-2);text-decoration:none}.breadcrumbs a:hover{color:var(--text)}.breadcrumbs__sep{opacity:.6;block-size:.85em;inline-size:.85em}.site-main{padding-block:var(--space-5)var(--space-8)}.doc{grid-template-columns:[full-start]minmax(0,1fr)[wide-start text-start]minmax(min(100%,var(--measure)),var(--measure))[text-end aside-start]minmax(0,calc(var(--wide) - var(--measure)))[aside-end wide-end]minmax(0,1fr)[full-end];display:grid;container:doc/inline-size}.doc>*{grid-column:text;min-inline-size:0}@media (min-width:64rem){.doc{--hero-pull:max(0px,22.5rem - (min(100cqi,var(--wide)) - var(--measure)))}.doc>.hero{grid-area:span 3/aside;margin-inline-start:calc(var(--space-6) - var(--hero-pull))}.doc:has(>.hero)>:is(.doc-header,.doc-review,.fact-sheet){margin-inline-end:var(--hero-pull)}.doc:has(>.hero):not(:has(>.fact-sheet))>.summary-box{margin-inline-end:var(--hero-pull)}.doc:has(>.hero){grid-template-rows:auto auto 1fr}.doc:has(>.hero):has(>:first-child+.doc-header){grid-template-rows:auto auto auto 1fr}.doc:has(>.hero):has(>:first-child+*+.doc-header){grid-template-rows:auto auto auto auto 1fr}.doc>:is(.doc-header,.doc-review,.fact-sheet,.summary-box){align-self:start}.doc>.toc{grid-column:aside;align-self:start;margin-inline-start:var(--space-6)}.doc:has(>.hero):not(:has(>.fact-sheet))>.toc{grid-column:text;margin-inline-start:0}}.prose{grid-template-columns:subgrid;grid-column:full;display:grid}.prose>*,.csec>*{grid-column:text;min-inline-size:0}.csec{grid-column:full;grid-template-columns:subgrid;display:grid}.site-footer{border-block-start:1px solid var(--line);background:var(--surface);margin-block-start:var(--space-8)}.site-footer__inner{max-inline-size:calc(var(--wide) + 2*var(--pad));padding:var(--space-6)var(--pad)var(--space-7);gap:var(--space-6);margin-inline:auto;display:grid}.independence-marker a{border-radius:var(--radius);border:1px solid var(--line);border-inline-start:3px solid var(--line-strong);background:var(--ground);color:var(--text);font-size:var(--s--1);padding:.6rem 1.1rem;font-weight:500;text-decoration:none;display:inline-flex}.independence-marker a:hover{border-color:var(--line-strong)}.site-footer__cols{gap:var(--space-6);grid-template-columns:repeat(auto-fit,minmax(12rem,1fr));display:grid}.site-footer__heading{font-size:var(--s--1);color:var(--text);margin-block-end:var(--space-3);font-weight:600}.site-footer__col li{margin-block:.35rem}.site-footer__col a{color:var(--text-2);font-size:var(--s--1);text-decoration:none}.site-footer__col a:hover{color:var(--text)}.site-footer__privacy,.site-footer__notice{font-size:var(--s--1);color:var(--text-2);max-inline-size:var(--measure)}.root-chooser{max-inline-size:30rem;padding-inline:var(--pad);margin:18vh auto}.root-chooser h1{font-size:var(--s-3);letter-spacing:-.03em;margin-block-end:var(--space-5);font-weight:600}.root-chooser__list{gap:var(--space-2);display:grid}.root-chooser__list a{padding:var(--space-4);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);color:var(--text);text-decoration:none;display:block}.site-tools__open{font:inherit;font-size:var(--s--1)}.site-tools__open .icon,.site-tools__close .icon{block-size:1.1rem;inline-size:1.1rem}.site-tools:popover-open{padding:var(--space-4)var(--pad)var(--space-5);background:var(--surface);color:var(--text);border:0;border-block-end:1px solid var(--line);box-shadow:var(--shadow-raised);font-size:var(--s-0);transition:transform .5s var(--spring),opacity .25s var(--ease),overlay .5s allow-discrete,display .5s allow-discrete;border-end-end-radius:var(--radius);border-end-start-radius:var(--radius)}@starting-style{.site-tools:popover-open{opacity:0;transform:translateY(-1.5rem)}}.site-tools::backdrop{background:var(--backdrop)}.site-tools__head{margin-block-end:var(--space-2)}.site-tools__title{font-size:var(--s--1);color:var(--text-2);font-weight:600}.site-tools__close{border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);block-size:2.75rem;inline-size:2.75rem;color:var(--text);place-items:center;padding:0;display:inline-grid}:is(.site-tools:popover-open>.utility-nav__search,.site-tools:popover-open .disclosure__summary,.site-tools:popover-open .scheme-toggle){min-block-size:3.25rem;inline-size:100%;padding-inline:var(--space-4);border-radius:var(--radius-sm);background:var(--surface);border:1px solid var(--line);color:var(--text);font:inherit;font-size:var(--s-0);text-align:start;align-items:center;gap:.75em;margin-block-start:var(--space-2);display:flex;transform:none}.site-tools:popover-open .disclosure__panel{padding:var(--space-1);background:var(--ground);border-color:var(--line);box-shadow:none;margin-block-start:var(--space-1)}.site-tools:popover-open .disclosure__panel a{font-size:var(--s-0)}@media (max-width:37.49rem){.primary-nav__list{padding-block:var(--space-1)var(--space-2);gap:2px}.primary-nav{--nav-pad:.45rem}.primary-nav__item a{padding-block:.3rem}.site-header__inner{gap:var(--space-2)var(--space-3)}.brand{line-height:1.1}.brand__name{inline-size:min-content}.utility-nav{flex-wrap:nowrap}}@media (max-width:30rem){.site-header__inner{padding-block:var(--space-3)var(--space-2)}.brand{gap:var(--space-2);font-size:var(--s--1);letter-spacing:-.01em}.brand-mark{block-size:1.75rem;inline-size:1.75rem}.utility-nav__alert{padding-inline:.75rem}.site-tools__open{justify-content:center;min-block-size:2.75rem;inline-size:2.75rem;padding:0}.site-tools__open-text{clip-path:inset(50%);white-space:nowrap;block-size:1px;inline-size:1px;position:absolute;overflow:hidden}}.qty,.seq,.ref__doi,time,.data-table td.study-table__n{font-family:var(--font-mono);font-variant-numeric:tabular-nums;font-size:max(.94em,.875rem)}:where(sub,sup){font-size:max(.75em,.75rem)}.seq{color:var(--text)}:root{--glyph-pending:url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16'%3E%3Ccircle cx='8' cy='8' r='6.25' fill='none' stroke='%23000' stroke-width='1.5'/%3E%3Cpath d='M8 4.4V8l2.6 1.6' fill='none' stroke='%23000' stroke-width='1.5' stroke-linecap='round'/%3E%3C/svg%3E")}.notice{margin-block:0 var(--space-5);padding:var(--space-3)var(--space-4);border-radius:var(--radius);background:var(--surface-2);color:var(--text-2);font-size:var(--s--1);border:1px solid var(--line)}.notice--stub{border:1px dashed var(--text-3);background:var(--surface)}.opinion-flag{padding:var(--space-5);border-radius:var(--radius);background:repeating-linear-gradient(135deg,var(--surface),var(--surface)12px,var(--surface-2)12px,var(--surface-2)24px);border:1px solid var(--line-strong);margin-block-end:var(--space-6)}.opinion-flag__label{border-radius:var(--radius-sm);background:var(--text);color:var(--ground);font-weight:700;font-size:var(--s--1);letter-spacing:.04em;padding:.15rem .7rem;display:inline-block}.opinion-flag__text{color:var(--text-2);font-size:var(--s--1);margin-block-start:var(--space-3)}.doc-header{padding-block:var(--space-2)var(--space-5)}.doc-header__eyebrow{font-size:var(--s--1);letter-spacing:.01em;color:var(--text-2);align-items:center;gap:.55em;margin-block-end:var(--space-3);font-weight:600;display:inline-flex}.doc-header__eyebrow:before{content:"";background:var(--res-hydrophobic);border-radius:50%;flex:none;block-size:.55rem;inline-size:.55rem}.doc-header__title{font-size:var(--s-4);letter-spacing:-.022em;text-wrap:balance;font-weight:600;line-height:1.08}.doc-header__byline{color:var(--text-2);margin-block-start:var(--space-4)}.compound-badge{border-radius:var(--radius);font-size:var(--s--1);background:var(--surface);color:var(--text-2);border:1px dashed var(--text-3);align-items:center;gap:.5em;margin-block-start:var(--space-4);padding:.35rem .8rem;font-weight:600;display:inline-flex}.compound-badge__icon{color:var(--text-3);line-height:0;display:inline-flex}.compound-badge__icon .pictogram{block-size:1.35em;inline-size:1.35em}.compound-badge[data-category=authorised]{background:var(--cyan-text);color:var(--cyan-ink);border:1px solid var(--cyan-text)}.compound-badge[data-category=authorised] .compound-badge__icon{color:inherit}.compound-badge[data-category=authorised-elsewhere]{color:var(--cyan-text);border:1.5px solid var(--cyan)}.compound-badge[data-category=authorised-elsewhere] .compound-badge__icon{color:var(--cyan)}.compound-badge[data-category=authorised-nationally]{color:var(--text);border:1.5px solid var(--text-3)}.compound-badge[data-category=authorised-nationally] .compound-badge__icon{color:var(--text-2)}.compound-facts{gap:var(--space-3);grid-template-columns:repeat(auto-fill,minmax(11rem,1fr));margin-block-start:var(--space-5);display:grid}.compound-facts>div{padding:var(--space-3);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line)}.compound-facts dt{font-size:var(--s--2);color:var(--text-3);margin-block-end:.2rem}.compound-facts dd{font-size:var(--s--1)}.review-meta__list{gap:var(--space-1)var(--space-5);font-size:var(--s--1);color:var(--text-2);flex-wrap:wrap;margin-block-start:var(--space-5);display:flex}.review-meta__item{flex-wrap:wrap;align-items:center;gap:.2em .4em;display:flex}.review-meta__item dt{color:var(--text-3)}.review-meta__item dt:after{content:":"}.review-meta__notice{color:var(--text-3);font-size:var(--s--2);margin-block-start:var(--space-2);line-height:1.5}.doc>.doc-review{margin-block:calc(-1*var(--space-2))var(--space-6);border-block-start:1px solid var(--line);padding-block-start:var(--space-3)}.doc-review .review-meta__list{column-gap:var(--space-4);font-size:var(--s--1);margin-block-start:0;line-height:1.5}@media (min-width:64rem){.doc>.doc-header{padding-block-end:var(--space-4)}.doc>.doc-review{margin-block:0 var(--space-4);padding-block:var(--space-3)0}}.toc{padding-block:var(--space-4)var(--space-3);border-block:1px solid var(--line);margin-block-end:var(--space-6)}.toc__title{font-size:var(--s--1);color:var(--text-2);margin-block-end:var(--space-2);font-weight:600}.toc__list{columns:2 17rem;column-gap:var(--space-6);margin:0;padding:0;list-style:none}@media (min-width:64rem){:is(.doc:not(:has(>.hero))>.toc,.doc:has(>.fact-sheet)>.toc){padding-block:var(--space-1)0;border-block:0;border-inline-start:1px solid var(--line);padding-inline-start:var(--space-5)}:is(.doc:not(:has(>.hero))>.toc .toc__list,.doc:has(>.fact-sheet)>.toc .toc__list){columns:auto}}.toc__list li{break-inside:avoid;font-size:var(--s--1);padding-block:.3rem;line-height:1.4}.toc__list a{color:var(--link);text-decoration:none}.toc__list a:hover{text-decoration:underline}:where(.prose) :where(p,li){color:var(--text)}:where(.prose,.csec,.in-detail__body)>p{margin-block:0 var(--space-5)}:where(.prose,.csec,.in-detail__body)>:is(ul,ol){margin-block:0 var(--space-5);padding-inline-start:1.3em}:where(.prose,.csec) li{margin-block:.4rem}:where(.prose,.csec) li::marker{color:var(--text-3)}:where(.prose,.csec,.in-detail__body,.callout__body,.faq__a,.diagram__text)>h2{font-size:var(--s-3);letter-spacing:-.015em;margin-block:var(--space-8)var(--space-4);font-weight:600;line-height:1.2}:where(.prose,.csec,.in-detail__body,.callout__body,.faq__a,.diagram__text)>h3{font-size:var(--s-1);letter-spacing:-.01em;margin-block:var(--space-6)var(--space-3);font-weight:600;line-height:1.3}:where(.prose,.csec,.in-detail__body,.callout__body,.faq__a,.diagram__text)>h4{font-size:var(--s-0);margin-block:var(--space-5)var(--space-2);font-weight:600}:where(.prose)>h2:first-child{margin-block-start:var(--space-4)}.prose strong{color:var(--text);font-weight:600}.prose blockquote{margin:0 0 var(--space-5);padding:var(--space-3)var(--space-5);border-inline-start:3px solid var(--line-strong);color:var(--text-2)}.prose table:not(.data-table){inline-size:100%;font-size:var(--s--1);border-collapse:separate;border-spacing:0;border:1px solid var(--line);border-radius:var(--radius);margin-block-end:var(--space-5);overflow:hidden}.prose table:not(.data-table) th,.prose table:not(.data-table) td{text-align:start;vertical-align:top;padding:var(--space-3);border-block-end:1px solid var(--line)}.prose table:not(.data-table) th{background:var(--surface-2);font-weight:600}.csec{margin-block-start:var(--space-8)}.csec__title{align-items:baseline;gap:var(--space-3);border-block-start:1px solid var(--line);font-size:var(--s-3);letter-spacing:-.015em;margin-block:0 var(--space-4);padding-block-start:var(--space-4);font-weight:600;line-height:1.2;display:flex}.csec__num{border:1px solid var(--line-strong);background:var(--surface-2);block-size:1.6em;inline-size:1.6em;font-family:var(--font-mono);color:var(--text);font-variant-numeric:tabular-nums;border-radius:50%;flex:none;place-items:center;font-size:max(.55em,.875rem);font-weight:600;display:inline-grid;translate:0 -.1em}.csec__intro{padding:var(--space-3)var(--space-4);border-radius:var(--radius);background:var(--surface-2);color:var(--text-2);font-size:var(--s--1);margin-block-end:var(--space-5)}.cite__marks{vertical-align:super;margin-inline-start:.1em;font-size:max(.62em,.75rem);line-height:0}.cite__link{color:var(--link);padding-inline:.12em;text-decoration:none}.cite__link:hover{text-decoration:underline}.cite-line{margin-block:calc(-1*var(--space-2))var(--space-5);font-size:var(--s--1);color:var(--text-2);line-height:1.5}.cite-line .cite__marks{font-size:inherit;vertical-align:baseline;line-height:inherit;margin-inline-start:0}.cite-line .cite__link{text-underline-offset:.15em;padding-inline:.1em;text-decoration:underline}.claim-badge{border-radius:var(--radius-pill);vertical-align:.1em;white-space:nowrap;background:var(--surface);border:1px solid var(--line);color:var(--text-2);align-items:center;gap:.35em;margin-inline-start:.2em;padding-block:0;padding-inline:.45em .55em;font-size:max(.75em,.875rem);font-weight:600;line-height:1.55;display:inline-flex}.claim-badge:before{content:"";background:var(--cyan);border-radius:50%;flex:none;block-size:.6em;inline-size:.6em}.claim-badge[data-level=hypothesis]{color:var(--amber-text);border-color:color-mix(in srgb,var(--amber)45%,var(--line))}.claim-badge[data-level=hypothesis]:before{box-shadow:inset 0 0 0 1.5px var(--amber);background:0 0}.claim-badge[data-level=in-vitro]:before{border:1.5px dotted var(--cyan);background:0 0}.claim-badge[data-level=animal]:before{border:1.5px dashed var(--cyan);background:0 0}.claim-badge[data-level=established]{color:var(--text);border-color:var(--line-strong)}a.term{color:inherit;-webkit-text-decoration:underline dotted var(--text-3);text-decoration:underline dotted var(--text-3);text-underline-offset:.22em}a.term:hover{color:var(--link)}.term-tip{max-inline-size:22rem;padding:var(--space-3)var(--space-4);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line-strong);box-shadow:var(--shadow-raised);font-size:var(--s--1);color:var(--text);line-height:1.5}.compound-glance{gap:var(--space-6);margin-block:var(--space-2)var(--space-6);grid-column:wide;display:grid}.grade{padding:var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);gap:var(--space-4);margin:0;display:grid}.grade__head{justify-content:space-between;align-items:baseline;gap:var(--space-2)var(--space-5);flex-wrap:wrap;display:flex}.grade__title{font-size:var(--s-2);letter-spacing:-.025em;font-weight:600}.grade__subtitle{color:var(--text-2);font-size:var(--s--1)}.grade__axes{gap:var(--space-3);margin:0;display:grid}.grade__axis{gap:var(--space-3)var(--space-4);padding:var(--space-4);border-radius:var(--radius-sm);background:var(--ground);border:1px solid var(--line);grid-template-columns:minmax(0,1fr) auto;grid-template-areas:"name value""scale scale""why why";display:grid}.grade__name{grid-area:name;display:grid}.grade__name-text{font-weight:600}.grade__question{color:var(--text-2);font-size:var(--s--1)}.grade__value{font-size:var(--s--1);color:var(--text);text-align:end;grid-area:value;align-self:start;font-weight:600}.grade__scale{grid-area:scale;margin:0}.grade__steps{grid-auto-columns:minmax(0,1fr);grid-auto-flow:column;gap:4px;margin:0;padding:0;list-style:none;display:grid}.grade__step{grid-template-rows:auto auto;align-content:start;gap:.4rem;min-inline-size:0;display:grid}.grade__step:before{content:"";border:1px solid var(--line-strong);background:var(--surface);border-radius:2px;block-size:.7rem}.grade__step[data-on]:before{background:var(--cyan);border-color:var(--cyan)}.grade__axis[data-step="0"] .grade__step[data-on]:before{border-color:var(--text-3);background:repeating-linear-gradient(-45deg,var(--text-3)0 1.5px,transparent 1.5px 5px),var(--surface)}.grade__step[data-current]:before{box-shadow:0 0 0 2px var(--ground),0 0 0 3.5px var(--text)}.grade__step-label{clip-path:none;block-size:auto;inline-size:auto;font-size:var(--s--2);color:var(--text-3);overflow-wrap:anywhere;-webkit-hyphens:auto;hyphens:auto;line-height:1.3;position:static;overflow:visible}.grade__step[data-on] .grade__step-label{color:var(--text-2)}.grade__step[data-current] .grade__step-label{color:var(--text);font-weight:600}@container doc (width<=40rem){.grade{padding:var(--space-4)}.grade__axis{gap:var(--space-2);padding:var(--space-3)var(--space-4)var(--space-4);grid-template-columns:minmax(0,1fr);grid-template-areas:"name""value""scale""why"}.grade__value{text-align:start}.grade__steps{grid-auto-columns:auto;grid-auto-flow:row;gap:3px}.grade__step{align-items:center;gap:var(--space-3);grid-template-rows:auto;grid-template-columns:2.75rem minmax(0,1fr)}}.grade__why{max-inline-size:var(--measure);font-size:var(--s--1);color:var(--text-2);grid-area:why;margin:0}.grade__foot{font-size:var(--s--1);color:var(--text-2)}.grade--compact{padding:var(--space-4)}.grade--compact .grade__step-label{clip-path:inset(50%);block-size:1px;inline-size:1px;position:absolute;overflow:hidden}.sequence{padding:var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);margin:0}.sequence__head{justify-content:space-between;gap:var(--space-4);margin-block-end:var(--space-3);display:flex}.sequence__title{font-weight:600}.sequence__length{font-size:var(--s--1);color:var(--text-2);white-space:nowrap}.sequence__visual{margin-block:var(--space-2)var(--space-4)}.seq-beads{block-size:auto;inline-size:100%;overflow:visible}.seq-beads__backbone{stroke:var(--line-strong);stroke-width:2.5px;stroke-linecap:round;stroke-linejoin:round}.seq-beads__bead{stroke:var(--surface);stroke-width:2px}.seq-beads__bead.is-hydrophobic,.seq-key__bead.is-hydrophobic{fill:var(--res-hydrophobic)}.seq-beads__bead.is-aromatic,.seq-key__bead.is-aromatic{fill:var(--res-aromatic)}.seq-beads__bead.is-polar,.seq-key__bead.is-polar{fill:var(--res-polar)}.seq-beads__bead.is-positive,.seq-key__bead.is-positive{fill:var(--res-positive)}.seq-beads__bead.is-negative,.seq-key__bead.is-negative{fill:var(--res-negative)}.seq-beads__bead.is-special,.seq-key__bead.is-special{fill:var(--res-special)}.seq-beads__bead.is-nonstandard,.seq-key__bead.is-nonstandard{fill:var(--surface);stroke:var(--res-nonstandard);stroke-width:2.5px}.seq-beads__bead.is-d{stroke:var(--res-nonstandard);stroke-dasharray:3 2}.seq-beads__charge,.seq-key__charge{fill:none;stroke:var(--surface);stroke-width:2.2px;stroke-linecap:round;pointer-events:none}.seq-beads__bead,.seq-beads__charge{transform-box:fill-box;transform-origin:50%}.seq-key{gap:var(--space-2)var(--space-5);margin:var(--space-3)0 0;font-size:var(--s--2);color:var(--text-2);flex-wrap:wrap;padding:0;list-style:none;display:flex}.seq-key__item{align-items:center;gap:.45em;display:inline-flex}.seq-key__svg{flex:none;block-size:1.15rem;inline-size:1.15rem;overflow:visible}.seq-key__bead{stroke:var(--surface);stroke-width:1.5px}.seq-key__bead.is-dform{fill:var(--surface);stroke:var(--res-nonstandard);stroke-width:2px;stroke-dasharray:3 2}.sequence__text{font-size:var(--s--1);color:var(--text)}.sequence__term{color:var(--text-2)}.sequence__read{font-size:var(--s--2);color:var(--text-2);margin-block-start:var(--space-1)}.sequence__notes{gap:var(--space-2);font-size:var(--s--1);margin-block-start:var(--space-3);display:grid}.sequence__notes dt{color:var(--text-2);font-size:var(--s--2)}.sequence__notes dd>.qty{font-family:inherit;font-size:inherit;font-weight:600}.mechanism{margin:var(--space-4)0 var(--space-7);grid-column:wide}.mechanism__caption{font-size:var(--s-1);letter-spacing:-.015em;font-weight:600}.mechanism__legend{margin-block:var(--space-2)var(--space-5);font-size:var(--s--1);color:var(--text-2);max-inline-size:var(--measure)}.mechanism__body{gap:var(--space-5);display:grid}@container doc (width>=52rem){.mechanism__body{gap:var(--space-6);grid-template-columns:minmax(18rem,5fr) minmax(0,6fr);align-items:start}.mechanism.is-live .mechanism__stage-wrap{position:sticky;inset-block-start:4vh}.mechanism.is-live .mechanism__step{align-content:center;min-block-size:55vh;display:grid}}@container doc (width<=52rem){.mechanism.is-live .mechanism__stage-wrap{z-index:2;margin-inline:calc(-1*var(--pad));padding:var(--space-2)var(--pad);background:var(--ground);border-block-end:1px solid var(--line);position:sticky;inset-block-start:0}.mechanism.is-live .mechanism__step{min-block-size:40vh}.mechanism.is-live .mechanism__steps{padding-block-end:30vh}}.mechanism-stage{border-radius:var(--radius);background:var(--ground);border:1px solid var(--line);padding:var(--space-3)var(--space-3)var(--space-4)}.stage__canvas{aspect-ratio:600/560;direction:ltr;inline-size:min(100%,max(17rem,94.2857vh - 9.64286rem));margin-inline:auto;position:relative;container-type:inline-size}@container doc (width<=52rem){.mechanism.is-live .stage__canvas{inline-size:min(100%,max(17rem,36.4286vh))}}.mechanism-stage .stage{block-size:100%;inline-size:100%;display:block;position:absolute;inset:0;overflow:visible}.stage__ligand circle{fill:var(--res-hydrophobic)}.stage__membrane circle{fill:var(--surface-2);stroke:var(--line-strong);stroke-width:1px}.stage__membrane line{stroke:var(--line-strong);stroke-width:1.5px}.stage__receptor{stroke:var(--res-aromatic);stroke-width:4px;stroke-linejoin:round}.stage__node{fill:var(--surface-2);stroke:var(--line-strong);stroke-width:1.5px}.stage__cascade{stroke:var(--line-strong);stroke-width:1.5px}.stage__nucleus{fill:var(--surface);stroke:var(--line-strong);stroke-width:1.5px}.stage__dna{stroke:var(--res-polar);stroke-width:2px}.stage__cell{fill:var(--surface);stroke:var(--line-strong);stroke-width:1.2px}.stage__body{fill:none;stroke:var(--line-strong);stroke-width:2px}.stage__leader{stroke:var(--text-3);stroke-width:1px}.stage__leader-dot{fill:var(--text-3)}.stage__zone{transition:opacity .6s var(--ease)}.stage__zone.is-active :is(.stage__node,.stage__nucleus,.stage__cell,.stage__body,.stage__membrane circle){stroke:var(--text)}.mechanism-stage.is-live .stage__lead:not(.is-active){opacity:.6}.stage__link{fill:none;stroke-width:3px;stroke-linecap:round;stroke:var(--cyan)}.stage__link[data-level=animal]{stroke-dasharray:10 7;stroke-linecap:butt}.stage__link[data-level=in-vitro]{stroke-dasharray:.1 7}.stage__link.is-hypothesis{stroke:var(--amber);stroke-dasharray:.1 7}.stage__label{inline-size:var(--w);color:var(--text-2);text-align:end;overflow-wrap:break-word;pointer-events:none;transition:color .3s var(--ease);font-size:clamp(.875rem,3.2cqi,1rem);font-weight:500;line-height:1.2;display:block;position:absolute;inset-block-start:var(--y);inset-inline-start:var(--x);translate:0 -50%}.stage__label[data-align=start]{text-align:start}.mechanism-stage.is-live .stage__label{color:var(--text-3)}.mechanism-stage.is-live .stage__label.is-active{color:var(--text)}.stage__pin{background:var(--cyan);block-size:max(1.65rem,6.4cqi);inline-size:max(1.65rem,6.4cqi);color:var(--cyan-ink);border:2px solid var(--cyan);font-family:var(--font-mono);font-variant-numeric:tabular-nums;pointer-events:none;border-radius:50%;place-items:center;font-size:max(.75rem,3.1cqi);font-weight:700;line-height:1;display:grid;position:absolute;inset-block-start:var(--y);inset-inline-start:var(--x);translate:-50% -50%}.stage__pin.is-hypothesis{background:var(--ground);color:var(--amber);border:2px dashed var(--amber)}.mechanism-stage.is-live :is(.stage__pin,.stage__link){transition:opacity .5s var(--ease),scale .6s var(--spring),background-color .3s var(--ease),color .3s var(--ease)}.mechanism-stage.is-live .stage__pin:not(.is-on){background:var(--ground);color:var(--text-3);border:2px solid var(--line-strong)}.mechanism-stage.is-live .stage__pin.is-current{box-shadow:0 0 0 3px var(--ground),0 0 0 5px var(--text);scale:1.15}.mechanism-stage.is-live .stage__link:not(.is-on){opacity:0}.stage-key{gap:var(--space-2)var(--space-4);margin:var(--space-3)0 0;padding:var(--space-3)var(--space-2)0;border-block-start:1px solid var(--line);font-size:var(--s--2);color:var(--text-2);flex-wrap:wrap;line-height:1.3;list-style:none;display:flex}.stage-key__item{align-items:center;gap:.5em;display:inline-flex}.stage-key__line{flex:none;block-size:.75rem;inline-size:2rem;overflow:visible}.stage-key__line path{fill:none;stroke:var(--cyan);stroke-width:3px;stroke-linecap:round}.stage-key__line[data-level=animal] path{stroke-dasharray:7 5;stroke-linecap:butt}.stage-key__line[data-level=in-vitro] path{stroke-dasharray:.1 6}.stage-key__line[data-level=hypothesis] path{stroke:var(--amber);stroke-dasharray:.1 6}.stage-key__ring{border:2px dashed var(--amber);border-radius:50%;flex:none;block-size:1rem;inline-size:1rem}.stage-key__pin{background:var(--cyan);block-size:1.5rem;inline-size:1.5rem;color:var(--cyan-ink);font-family:var(--font-mono);border-radius:50%;flex:none;place-items:center;font-size:.75rem;font-weight:700;display:inline-grid}.stage-now{margin:var(--space-3)0 0;padding-inline:var(--space-2);font-size:var(--s--1);color:var(--text);line-height:1.4}.stage-key__item:first-child,.stage-key__item--pin,.stage-key__lead{flex-basis:100%}.stage-key__pin.is-hypothesis{background:var(--ground);color:var(--amber);border:2px dashed var(--amber)}@container doc (width<=52rem){.mechanism-stage{padding:var(--space-2)}.mechanism.is-live .stage-key{gap:var(--space-1)var(--space-3);margin-block-start:var(--space-2);padding-block-start:var(--space-2)}.mechanism.is-live :is(.stage-key__item:first-child,.stage-key__item--pin,.stage-key__lead){display:none}.mechanism.is-live .stage-now{margin-block-start:var(--space-2)}.mechanism.is-live .stage__pin{block-size:max(1.375rem,6.4cqi);inline-size:max(1.375rem,6.4cqi)}.mechanism-stage.is-live .stage__pin.is-current{box-shadow:0 0 0 2px var(--ground),0 0 0 3.5px var(--text);scale:1.08}}.mechanism__steps{gap:var(--space-4);counter-reset:step;margin:0;padding:0;list-style:none;display:grid}.mechanism__step{padding:var(--space-4)var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);border-inline-start:4px solid var(--cyan);transition:border-color .4s var(--ease),background .4s var(--ease)}.mechanism__step[data-level=animal]{border-inline-start-style:dashed}.mechanism__step[data-level=in-vitro]{border-inline-start-style:dotted}.mechanism__step[data-level=hypothesis]{border-inline-start:4px dotted var(--amber)}.mechanism.is-live .mechanism__step:not(.is-current){background:0 0}.mechanism.is-live .mechanism__step.is-current{background:var(--surface);border-color:var(--line-strong);border-inline-start-color:var(--cyan)}.mechanism.is-live .mechanism__step.is-current[data-level=hypothesis]{border-inline-start-color:var(--amber)}.mechanism__meta{gap:var(--space-2);font-size:var(--s--2);color:var(--text-2);flex-wrap:wrap;align-items:center;display:flex}.mechanism__n{color:var(--text);font-weight:700}.mechanism__kind{color:var(--text-2)}.level-badge{border-radius:var(--radius-sm);background:var(--cyan-soft);color:var(--cyan-text);align-items:center;gap:.4em;padding:.05rem .55rem;font-weight:600;display:inline-flex}.level-badge:before{content:"";border-block-start:2.5px solid;flex:none;inline-size:1.1em}.level-badge[data-level=animal]:before{border-block-start-style:dashed}.level-badge[data-level=in-vitro]:before{border-block-start-style:dotted}.level-badge[data-level=hypothesis]{background:var(--amber-soft);color:var(--amber-text)}.level-badge[data-level=hypothesis]:before{border-block-start-style:dotted}.mechanism__title{font-size:var(--s-1);letter-spacing:-.015em;margin-block:var(--space-2);font-weight:600;line-height:1.25}.mechanism__detail{color:var(--text-2);font-size:var(--s--1);line-height:1.6}.table-scroll{margin-block-end:var(--space-6)}.data-table{inline-size:100%;font-size:var(--s--1);border-collapse:separate;border-spacing:0}.data-table caption{text-align:start;font-weight:600;font-size:var(--s-0);padding-block-end:var(--space-3)}.data-table th,.data-table td{text-align:start;vertical-align:top;padding:var(--space-3);border-block-end:1px solid var(--line)}.data-table thead th{color:var(--text-2);font-weight:600;font-size:var(--s--1);white-space:nowrap}.data-table tbody tr{transition:background .2s var(--ease)}.data-table tbody tr:hover{background:var(--surface)}.study-table,.reg-table{grid-column:wide}.study-table__summary{color:var(--text-2);font-size:var(--s--1);margin-block-end:var(--space-3)}.study-table__table{min-inline-size:58rem}.study-table__table tbody tr[data-species=human]>th{border-inline-start:3px solid var(--cyan)}.study-table__table tbody tr:not([data-species=human])>th{border-inline-start:3px dashed var(--cyan)}.study-table__ref{font-weight:600}.study-table__flags{color:var(--text-2)}.study-table__found{min-inline-size:16rem}.study-table__limits{min-inline-size:13rem;color:var(--text-2)}.reg-table__table{min-inline-size:40rem}.reg-table__since{font-size:var(--s--2);color:var(--text-2);display:block}.reg-table__note{color:var(--text-2)}.status-badge{border-radius:var(--radius-sm);background:var(--surface-2);border:1px solid var(--line);font-size:var(--s--2);white-space:nowrap;color:var(--text);align-items:center;gap:.35em;padding:.1rem .55rem;font-weight:600;display:inline-flex}.status-badge[data-status=authorised],.status-badge[data-status=in-force],.status-badge[data-status=adopted]{background:var(--cyan-soft);color:var(--cyan-text);border-color:#0000}.status-badge[data-status=prohibited]{background:var(--surface);border-color:var(--line-strong);color:var(--text)}.status-badge:is([data-status=not-authorised],[data-status=unclear],[data-status=refused],[data-status=withdrawn],[data-status=under-review],[data-status=investigational],[data-status=advisory-vote],[data-status=rulemaking],[data-status=consultation],[data-status=proposed],[data-status=stalled],[data-status=watching]){background:var(--surface);border:1px dashed var(--text-3);color:var(--text-2)}@container doc (width<=56rem){.study-table__table,.reg-table__table{min-inline-size:0}.study-table__table thead,.reg-table__table thead{display:none}.study-table__table tbody,.reg-table__table tbody{gap:var(--space-3);display:grid}.study-table__table tr,.reg-table__table tr{gap:var(--space-2);padding:var(--space-4);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);display:grid}.study-table__table th,.study-table__table td,.reg-table__table th,.reg-table__table td{padding:0;display:block;border:0!important}.study-table__table td:before,.reg-table__table td:before{content:attr(data-label);font-size:var(--s--2);color:var(--text-2);font-weight:600;display:block}}.authorised{margin-block:0 var(--space-7);padding:var(--space-5)var(--space-6);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);border-inline-start:4px solid var(--cyan);grid-column:wide}.authorised__badge{border-radius:var(--radius);background:var(--cyan-text);color:var(--cyan-ink);font-weight:700;font-size:var(--s--1);align-items:center;gap:.5em;padding:.3rem .8rem;display:inline-flex}.authorised--elsewhere .authorised__badge{color:var(--cyan-text);box-shadow:inset 0 0 0 1.5px var(--cyan);background:0 0}.authorised__check{block-size:1.1em;inline-size:1.1em}.authorised__explain{margin-block:var(--space-4);max-inline-size:var(--measure);color:var(--text)}.authorised__route{padding:var(--space-4)var(--space-5);border-radius:var(--radius);background:var(--surface-2);margin-block-end:var(--space-5)}.authorised__route-title{font-size:var(--s-0);margin-block-end:var(--space-2);font-weight:600}.authorised__route p{color:var(--text-2);font-size:var(--s--1)}.authorised__products{min-inline-size:36rem}.authorised__name{font-weight:600;display:block}.authorised__holder,.authorised__route-type{font-size:var(--s--2);color:var(--text-2);font-weight:400;display:block}.authorised .icon--external{vertical-align:-.1em;block-size:.9em;inline-size:.9em;margin-inline-start:.25em}.authorised{container:authorised/inline-size}@container authorised (width<=46rem){.authorised__products{min-inline-size:0}.authorised__products thead{display:none}.authorised__products,.authorised__products tbody{gap:var(--space-3);display:grid}.authorised__products tr{gap:var(--space-2);padding:var(--space-4);border-radius:var(--radius);border:1px solid var(--line);display:grid}.authorised__products :is(th,td){border:0;padding:0;display:block}.authorised__products td:before{content:attr(data-label);font-size:var(--s--2);color:var(--text-2);font-weight:600;display:block}.authorised .table-scroll{margin-block-end:0;overflow:visible}}.callout{margin-block:0 var(--space-6);padding:var(--space-4)var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line)}.callout__title{align-items:flex-start;gap:.5em;margin-block-end:var(--space-2);font-weight:600;line-height:1.35;display:flex}.callout__icon{flex:none;block-size:1.15em;inline-size:1.15em;margin-block-start:.1em}.callout__body>:last-child{margin-block-end:0}.callout__body p{color:var(--text-2);margin-block-end:var(--space-3)}.callout--uncertain{border:1px dashed var(--text-3)}.callout--uncertain .callout__icon{color:var(--text-3)}.callout--legal{border-color:var(--line-strong)}.callout--warning{border-inline-start:4px solid var(--text)}.callout--stop{border:2px solid var(--alert);background:var(--alert-tint)}.callout--stop .callout__title{color:var(--alert);font-size:var(--s-1)}.callout--stop .callout__body p{color:var(--text)}.diagram{margin:0 0 var(--space-7);padding:var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);grid-column:wide}.diagram__caption{margin-block-end:var(--space-3);font-weight:600}.diagram__art svg{max-inline-size:100%;margin-inline:auto;display:block}.diagram__text{font-size:var(--s--1);color:var(--text-2)}.diagram__text>:last-child{margin-block-end:0}.diagram__details summary{cursor:pointer;color:var(--link);font-size:var(--s--1);margin-block-start:var(--space-3)}.checklist{margin-block:0 var(--space-6);padding:var(--space-4)var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line)}.checklist__title{margin-block-end:var(--space-2);font-weight:600}.checklist ul{margin:0;padding:0;list-style:none}.checklist li{margin-block:var(--space-2);padding-inline-start:1.8rem;position:relative}.checklist li:before{content:"";border:2px solid var(--line-strong);border-radius:4px;block-size:1.05rem;inline-size:1.05rem;position:absolute;inset-block-start:.25em;inset-inline-start:0}.faq{margin-block:0 var(--space-6);gap:var(--space-3);display:grid}.faq__item{padding:var(--space-4)var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line)}.faq__q{font-size:var(--s-0);margin-block-end:var(--space-2);font-weight:600}.faq__a{color:var(--text-2)}.faq__a>:last-child{margin-block-end:0}.warning-signs{margin-block:var(--space-6);padding:var(--space-5);border-radius:var(--radius);background:var(--alert-tint);border:1px solid var(--alert)}.warning-signs__title{font-size:var(--s-1);color:var(--alert);align-items:center;gap:.5em;margin-block-end:var(--space-4);font-weight:600;display:flex}.warning-signs__title .icon{block-size:1.2em;inline-size:1.2em}.warning-signs__group{padding-block:var(--space-3);border-block-start:1px solid color-mix(in srgb,var(--alert)35%,var(--line))}.warning-signs__action{border-radius:var(--radius-sm);font-weight:700;font-size:var(--s--1);background:var(--surface);border:1px solid var(--line-strong);margin-block-end:var(--space-3);padding:.15rem .7rem;display:inline-block}.warning-signs__group[data-action=emergency] .warning-signs__action{background:var(--alert);border-color:var(--alert);color:var(--alert-ink)}.warning-signs__list{gap:var(--space-3);margin:0;padding:0;list-style:none;display:grid}.warning-signs__sign{font-weight:600}.warning-signs__why{color:var(--text-2);font-size:var(--s--1);margin-block-start:.15rem;display:block}.page-list{gap:var(--space-3);margin-block-end:var(--space-6);display:grid}.page-list__item{padding:var(--space-4)var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);transition:border-color .2s var(--ease),translate .4s var(--spring)}.page-list__item:hover{border-color:var(--line-strong);translate:0 -2px}.page-list__link{font-size:var(--s-1);color:var(--text);align-items:center;gap:.5em;font-weight:600;text-decoration:none;display:inline-flex}.page-list__link .icon{block-size:1em;inline-size:1em;color:var(--link)}.page-list__desc{color:var(--text-2);font-size:var(--s--1);margin-block-start:var(--space-1)}.compound-index{grid-column:wide}.compound-index__group{margin-block-end:var(--space-7)}.compound-index__title{font-size:var(--s-2);letter-spacing:-.025em;margin-block-end:var(--space-4);font-weight:600}.compound-cards{gap:var(--space-4);grid-template-columns:repeat(auto-fill,minmax(17rem,1fr));display:grid}.compound-card{align-content:start;gap:var(--space-2);padding:var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);transition:border-color .2s var(--ease),translate .5s var(--spring);display:grid;position:relative}.compound-card:hover{border-color:var(--line-strong);translate:0 -3px}.compound-card__link{font-size:var(--s-1);letter-spacing:-.02em;color:var(--text);font-weight:600;text-decoration:none}.compound-card__link:after{content:"";border-radius:inherit;position:absolute;inset:0}.compound-card__meta{gap:var(--space-2);font-size:var(--s--2);color:var(--text-2);flex-wrap:wrap;display:flex}.compound-card__stub{border-radius:var(--radius-sm);border:1px dashed var(--text-3);padding-inline:.5rem}.compound-card__desc{color:var(--text-2);font-size:var(--s--1)}.evidence-mini{font-size:var(--s--2);gap:.45rem;margin-block-start:var(--space-2);display:grid}.evidence-mini__axis{gap:0 var(--space-2);grid-template-columns:minmax(0,1fr) fit-content(55%);display:grid}.evidence-mini__axis dt{color:var(--text-2)}.evidence-mini__axis dd{color:var(--text);text-align:end;font-weight:600}.evidence-mini__axis:after{content:"";background:linear-gradient(90deg,var(--cyan)calc(8% + 92%*var(--frac)),var(--line)0);border-radius:2px;grid-column:1/-1;block-size:4px}[dir=rtl] .evidence-mini__axis:after{background:linear-gradient(270deg,var(--cyan)calc(8% + 92%*var(--frac)),var(--line)0)}.grade-matrix{grid-column:wide}.grade-matrix__controls{gap:var(--space-2);flex-wrap:wrap;align-items:center;margin-block-end:var(--space-3);display:flex}.grade-matrix__sort-label{color:var(--text-2);font-size:var(--s--1)}.grade-matrix__buttons{gap:var(--space-2);flex-wrap:wrap;display:flex}.grade-matrix__buttons button,.timeline__filters button,.news__filters button{border-radius:var(--radius);background:var(--surface);border:1px solid var(--line-strong);min-block-size:2.4rem;font-size:var(--s--1);transition:border-color .2s var(--ease);padding-inline:.9rem}.grade-matrix__buttons button[aria-pressed=true],.timeline__filters button[aria-pressed=true],.news__filters button[aria-pressed=true]{background:var(--text);color:var(--ground);border-color:var(--text)}.grade-matrix__note{color:var(--text-2);font-size:var(--s--1);margin-block-end:var(--space-3)}.grade-matrix__table{min-inline-size:46rem}.grade-matrix__table td{padding-block-end:1rem;position:relative}.grade-matrix__table td:after{content:"";block-size:4px;inline-size:calc((100% - 2*var(--space-3))*(.08 + .92*var(--frac)));background:var(--cyan);border-radius:2px;position:absolute;inset-block-end:.45rem;inset-inline-start:var(--space-3)}.grade-matrix__cell{font-family:var(--font-mono);font-size:.94em}.rubric{gap:var(--space-5);margin-block-end:var(--space-6);display:grid}.rubric__axis{padding:var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line)}.rubric__name{font-size:var(--s-1);font-weight:600}.rubric__question{color:var(--text-2);margin-block-end:var(--space-3)}.rubric__levels{gap:var(--space-2);padding:0;list-style:none;display:grid}.rubric__level{gap:var(--space-3);padding-block:var(--space-2);border-block-start:1px solid var(--line);font-size:var(--s--1);grid-template-columns:minmax(9rem,13rem) minmax(0,1fr);display:grid}.rubric__value{font-weight:600}.rubric__explain{color:var(--text-2)}@container doc (width<=40rem){.rubric__level{grid-template-columns:minmax(0,1fr)}}.rubric__claim-list{gap:var(--space-2);font-size:var(--s--1);padding:0;list-style:none;display:grid}.timeline{grid-column:wide}.timeline__filters{gap:var(--space-2);flex-wrap:wrap;align-items:center;margin-block-end:var(--space-5);display:flex}.timeline__count{color:var(--text-2);font-size:var(--s--1);margin-inline-start:auto}.timeline__decades ul{gap:var(--space-2);flex-wrap:wrap;margin-block-end:var(--space-5);display:flex}.timeline__decades a{border-radius:var(--radius-sm);background:var(--surface-2);color:var(--text-2);font-family:var(--font-mono);font-size:var(--s--2);padding:.2rem .7rem;text-decoration:none;display:inline-block}.timeline .timeline__list{gap:var(--space-4);grid-template-columns:minmax(0,1fr);padding-inline-start:var(--space-6);display:grid;position:relative}.timeline__list:before{content:"";background:var(--line);inline-size:2px;position:absolute;inset-block:0;inset-inline-start:.6rem}.timeline__event{padding:var(--space-4)var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);scroll-margin-block-start:2rem;position:relative}.timeline__event:before{content:"";background:var(--ground);border:2px solid var(--line-strong);border-radius:50%;block-size:.9rem;inline-size:.9rem;position:absolute;inset-block-start:1.4rem;inset-inline-start:calc(-1*var(--space-6) + .25rem)}.timeline__event[data-category=approval]:before{border-color:var(--cyan);background:var(--cyan)}.timeline__when{font-family:var(--font-mono);font-size:var(--s--1);color:var(--text);font-weight:700}.timeline__cat{font-size:var(--s--2);color:var(--text-2)}.timeline__title{font-size:var(--s-1);letter-spacing:-.015em;margin-block:var(--space-1);font-weight:600}.timeline__text{color:var(--text-2);font-size:var(--s--1)}.timeline__meta{gap:var(--space-2)var(--space-3);font-size:var(--s--2);flex-wrap:wrap;margin-block-start:var(--space-2);display:flex}.timeline__compound{border-radius:var(--radius-sm);background:var(--surface-2);padding-inline:.5rem;text-decoration:none}.timeline__sources{gap:var(--space-1)var(--space-3);flex-wrap:wrap;display:inline-flex}.timeline__sources a{color:var(--text-2)}.corrections__list,.tracker{gap:var(--space-3);padding:0;list-style:none;display:grid}.corrections__item,.tracker__item,.jurisdiction-card,.news__item,.news-sources__item{padding:var(--space-4)var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line)}.corrections__head,.tracker__head,.news__meta{gap:var(--space-2)var(--space-3);font-size:var(--s--2);color:var(--text-2);flex-wrap:wrap;align-items:center;display:flex}.corrections__summary,.tracker__title{font-weight:600;font-size:var(--s-0);margin-block:var(--space-1)}.corrections__detail,.tracker__summary{color:var(--text-2);font-size:var(--s--1)}.corrections__routes,.corrections__feed,.tracker__links{font-size:var(--s--2);gap:var(--space-2);flex-wrap:wrap;margin-block-start:var(--space-2);display:flex}.tracker__meta{gap:var(--space-1)var(--space-5);font-size:var(--s--2);color:var(--text-2);flex-wrap:wrap;margin-block-start:var(--space-2);display:flex}.tracker__meta dt{color:var(--text-2)}.jurisdiction-card{margin-block-end:var(--space-5)}.jurisdiction-card__title{margin-block-end:var(--space-2);font-weight:600}.jurisdiction-card__list{gap:var(--space-2);font-size:var(--s--1);display:grid}.jurisdiction-card__list>div{gap:var(--space-3);grid-template-columns:minmax(9rem,1fr) minmax(0,2fr);display:grid}.jurisdiction-card__list dt{color:var(--text-2)}.news__caution{padding:var(--space-4)var(--space-5);border-radius:var(--radius);background:var(--surface-2);border:1px solid var(--line-strong);color:var(--text);margin-block-end:var(--space-4)}.news__updated,.news__hint-note{color:var(--text-2);font-size:var(--s--1);margin-block:var(--space-3)}.news__filters{gap:var(--space-2);flex-wrap:wrap;margin-block-end:var(--space-4);display:flex}.news__list{gap:var(--space-3);display:grid}.news__cat{border-radius:var(--radius-sm);background:var(--surface-2);color:var(--text-2);padding:.05rem .55rem;font-weight:600}.news__cat[data-category=research]{background:var(--cyan-soft);color:var(--cyan-text)}.news__cat[data-category=preprint]{background:var(--surface);border:1px dashed var(--text-3)}.news__hint{border-radius:var(--radius-sm);border:1px solid var(--line-strong);padding:.05rem .55rem}.news__item[data-hint=animal] .news__hint{border:1.5px dashed var(--cyan);color:var(--cyan-text)}.news__item[data-hint=in-vitro] .news__hint{border:1.5px dotted var(--cyan);color:var(--cyan-text)}.news__title{font-size:var(--s-0);margin-block:var(--space-2)var(--space-1);font-weight:600;line-height:1.35}.news__title a{color:var(--text);text-decoration:none}.news__title a:hover{color:var(--link);text-decoration:underline}.news__title .icon{block-size:.8em;inline-size:.8em;color:var(--text-3);margin-inline-start:.35em}.news__summary{color:var(--text-2);font-size:var(--s--1)}.news__source{font-size:var(--s--2);color:var(--text-2);margin-block-start:var(--space-1)}.news-sources{margin-block-start:var(--space-8)}.news-sources h2{font-size:var(--s-2);letter-spacing:-.025em;margin-block-end:var(--space-3);font-weight:600}.news-sources__list{gap:var(--space-3);font-size:var(--s--1);margin-block-start:var(--space-4);display:grid}.news-sources__item dd{color:var(--text-2);margin-block-start:var(--space-1)}.glossary-index__letters ul{gap:var(--space-1);flex-wrap:wrap;margin-block-end:var(--space-6);display:flex}.glossary-index__letters a{border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);min-block-size:2.4rem;min-inline-size:2.4rem;color:var(--text);place-items:center;font-weight:600;text-decoration:none;display:inline-grid}.glossary-index__letters a:hover{border-color:var(--line-strong)}.glossary-index__letter{font-size:var(--s-3);color:var(--text);margin-block:var(--space-7)var(--space-3);font-weight:600}.glossary-index__list{gap:var(--space-3);grid-template-columns:minmax(0,1fr);display:grid}.glossary-index__entry{padding:var(--space-4)var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);scroll-margin-block-start:2rem}.glossary-index__entry:target{border-color:var(--focus);box-shadow:inset 0 0 0 1px var(--focus)}.glossary-index__term{font-weight:600;font-size:var(--s-0)}.glossary-index__aliases{color:var(--text-2);font-weight:400;font-size:var(--s--1)}.glossary-index__def{color:var(--text-2);margin-block:var(--space-1)}.glossary-index__cat,.glossary-index__see{font-size:var(--s--2);color:var(--text-2)}.source-list{margin-block-start:var(--space-8)}.source-list__title{font-size:var(--s-3);letter-spacing:-.03em;margin-block-end:var(--space-3);font-weight:600}.source-list__intro{color:var(--text-2);font-size:var(--s--1);margin-block-end:var(--space-5)}.source-list__items{gap:var(--space-3);font-size:var(--s--1);color:var(--text-2);grid-template-columns:minmax(0,1fr);padding-inline-start:2.2em;display:grid}.source-list__item{padding-inline-start:.3em;scroll-margin-block-start:2rem}.source-list__item::marker{font-family:var(--font-mono);color:var(--text-3)}.source-list__item:target{color:var(--text);background:var(--surface-2);border-radius:var(--radius-sm);outline:6px solid var(--surface-2)}.source-list__back{text-underline-offset:.15em;margin-inline-start:.4em;text-decoration:underline}.source-list__subtitle{font-size:var(--s-1);margin-block:var(--space-6)var(--space-3);font-weight:600}.ref__title{color:var(--text);font-style:normal}.ref__container{font-style:italic}.ref__type{border-radius:var(--radius-sm);background:var(--surface-2);color:var(--text-2);white-space:nowrap;padding-inline:.45rem;font-size:.94em}.ref__accessed{color:var(--text-2)}.sources-index{grid-column:wide}.sources-index__count{color:var(--text-2);margin-block-end:var(--space-4)}.sources-index__type{font-size:var(--s-2);letter-spacing:-.025em;margin-block:var(--space-7)var(--space-3);font-weight:600}.sources-index__n{font-family:var(--font-mono);color:var(--text-2);font-size:var(--s--1);font-weight:400}.sources-index__list{gap:var(--space-2);font-size:var(--s--1);color:var(--text-2);grid-template-columns:minmax(0,1fr);padding:0;list-style:none;display:grid}.sources-index__list li{padding:var(--space-3)var(--space-4);border-radius:var(--radius-sm);background:var(--surface)}.search{margin-block-end:var(--space-7)}.search__label{font-size:var(--s-1);margin-block-end:var(--space-3);font-weight:600;display:block}.search__row{gap:var(--space-2);display:flex}.search__input{min-block-size:3.25rem;min-inline-size:0;padding-inline:var(--space-4);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line-strong);color:var(--text);font-size:var(--s-0);flex:1}.search__button{min-block-size:3.25rem;padding-inline:var(--space-5);border-radius:var(--radius);background:var(--text);color:var(--ground);border:0;font-weight:700}.search__status{color:var(--text-2);margin-block:var(--space-3)}.search__results{gap:var(--space-3);display:grid}.search__result{padding:var(--space-4)var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line)}.search__result-title{font-weight:600;font-size:var(--s-0)}.search__excerpt{color:var(--text-2);font-size:var(--s--1)}.search__excerpt mark{background:color-mix(in srgb,var(--link)16%,transparent);color:var(--text);border-radius:3px}.search__all h2{font-size:var(--s-1);margin-block-end:var(--space-3);font-weight:600}.search__all-list{columns:2 16rem;font-size:var(--s--1)}.doc-footer{gap:var(--space-5);margin-block-start:var(--space-8);display:grid}.related__title{font-size:var(--s-2);letter-spacing:-.025em;margin-block-end:var(--space-4);font-weight:600}.related__list{gap:var(--space-3);grid-template-columns:repeat(auto-fill,minmax(16rem,1fr));display:grid}.related__item{padding:var(--space-4)var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);position:relative}.related__item a{color:var(--text);align-items:center;gap:.4em;font-weight:600;text-decoration:none;display:inline-flex}.related__item a:after{content:"";position:absolute;inset:0}.related__item .icon{color:var(--link);block-size:1em;inline-size:1em}.related__desc{color:var(--text-2);font-size:var(--s--1);margin-block-start:var(--space-1)}.doc-footer .review-meta{padding:var(--space-4)var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line)}.doc-footer .review-meta__list{margin-block-start:0}.standing-notice{gap:var(--space-3);padding:var(--space-4)var(--space-5);border-radius:var(--radius);background:var(--surface-2);color:var(--text-2);font-size:var(--s--1);align-items:flex-start;display:flex}.standing-notice .icon{block-size:1.2em;inline-size:1.2em;color:var(--link);flex:none;margin-block-start:.1em}.icon{vertical-align:-.15em;block-size:1.1em;inline-size:1.1em}.pictogram{fill:currentColor;block-size:1.5em;inline-size:1.5em}.hero picture,.photo picture,.plate picture,.media-credits__thumb{display:block}.hero__img,.photo__img,.plate__img,.media-credits__img{block-size:auto;inline-size:100%;display:block}.media-credit,.media-credit a{overflow-wrap:anywhere}.media-credit a.media-credit__details{white-space:nowrap;overflow-wrap:normal}.hero{min-inline-size:0;margin:0}.hero__frame{position:relative;overflow:hidden}.hero__img{aspect-ratio:16/9;object-fit:cover;object-position:var(--focal-narrow,50% 50%);max-block-size:24rem}@media (min-width:64rem){.hero__img{aspect-ratio:3/2;object-position:var(--focal-wide,50% 50%);max-block-size:none}}.hero__credit :is(.media-credit__org,.media-credit__via,.media-credit__lic){display:none}.hero__caption{justify-content:space-between;align-items:baseline;gap:.15rem var(--space-4,1rem);flex-wrap:wrap;display:flex}.hero__text{flex:18rem;min-inline-size:0}.hero__credit{flex:0 auto}.photo{min-inline-size:0;margin:0}.photo__frame{position:relative;overflow:hidden}.photo__caption{gap:.2rem;display:grid}.plate{min-inline-size:0;margin:0;container:plate/inline-size}.plate__body{gap:var(--space-4,1rem);align-items:start;display:grid}@container plate (width>=40rem){.plate__body{grid-template-columns:minmax(0,3fr) minmax(13rem,2fr)}.plate[data-shape=portrait] .plate__body{grid-template-columns:minmax(0,24rem) minmax(13rem,1fr)}}.plate[data-shape=portrait] .plate__art{justify-self:center;inline-size:100%;max-inline-size:24rem}.plate__art{min-inline-size:0;position:relative}.plate .plate__picture--light{display:var(--plate-show-light,block)}.plate .plate__picture--dark{display:var(--plate-show-dark,none)}@media print{:root .plate .plate__picture--light{display:block}:root .plate .plate__picture--dark{display:none}}.plate__markers{pointer-events:none;direction:ltr;block-size:100%;inline-size:100%;position:absolute;inset:0;overflow:visible}.plate__marker{transform-box:fill-box;transform-origin:50%}.plate__n{font-variant-numeric:tabular-nums;font-weight:700}.plate ol.plate__legend{gap:var(--space-3,.75rem);margin:0;padding:0;display:grid}.plate__item{gap:var(--space-3,.75rem);grid-template-columns:auto minmax(0,1fr);align-items:start;display:grid}.plate__num{font-variant-numeric:tabular-nums;direction:ltr;unicode-bidi:isolate;place-items:center;display:inline-grid}.plate__label{gap:.15rem;display:grid}.plate__words-summary{cursor:pointer}.plate__ref-n{font-size:.75em;line-height:0}.plate__art-note{display:block}.plate__marker,.plate__item{--on:0}.plate__item:hover{--on:1}.plate:has(.plate__item:first-child:hover) .plate__marker:first-of-type{--on:1}.plate:has(.plate__item:nth-child(2):hover) .plate__marker:nth-of-type(2){--on:1}.plate:has(.plate__item:nth-child(3):hover) .plate__marker:nth-of-type(3){--on:1}.plate:has(.plate__item:nth-child(4):hover) .plate__marker:nth-of-type(4){--on:1}.plate:has(.plate__item:nth-child(5):hover) .plate__marker:nth-of-type(5){--on:1}.plate:has(.plate__item:nth-child(6):hover) .plate__marker:nth-of-type(6){--on:1}.plate:has(.plate__item:nth-child(7):hover) .plate__marker:nth-of-type(7){--on:1}.plate:has(.plate__item:nth-child(8):hover) .plate__marker:nth-of-type(8){--on:1}.plate:has(.plate__item:nth-child(9):hover) .plate__marker:nth-of-type(9){--on:1}.media-credits ul.media-credits__list{gap:var(--space-5,1.5rem);margin:0;padding:0;display:grid}.media-credits__item{gap:var(--space-4,1rem);grid-template-columns:5.5rem minmax(0,1fr);align-items:start;scroll-margin-block-start:5rem;display:grid}.media-credits__img{aspect-ratio:1;object-fit:cover;object-position:var(--focal,50% 50%)}.media-credits__meta{gap:.2rem;display:grid}.media-credits__meta>div{gap:0 var(--space-3,.75rem);grid-template-columns:minmax(7rem,auto) minmax(0,1fr);display:grid}.media-credits__meta dd{overflow-wrap:anywhere;min-inline-size:0;margin:0}.media-credits ul.media-credits__sources{gap:.25rem;margin:0;padding:0;display:grid}@media (max-width:30rem){.media-credits__item{grid-template-columns:4rem minmax(0,1fr)}.media-credits__meta>div{grid-template-columns:minmax(0,1fr)}}@media print{.hero__img{max-block-size:6cm}.plate__words{display:block}}:root{--photo-filter:saturate(.92);--plate-panel:#fff;--plate-filter:none;--plate-show-light:block;--plate-show-dark:none}:root[data-scheme=dark]{--photo-filter:saturate(.9)brightness(.88);--plate-panel:#d9dee5;--plate-filter:brightness(.85);--plate-show-light:none;--plate-show-dark:block}:root[data-scheme=dark] .plate[data-dark-art]{--plate-panel:var(--surface);--plate-filter:none}@media (prefers-color-scheme:dark){:root:not([data-scheme=light]){--photo-filter:saturate(.9)brightness(.88);--plate-panel:#d9dee5;--plate-filter:brightness(.85);--plate-show-light:none;--plate-show-dark:block}:root:not([data-scheme=light]) .plate[data-dark-art]{--plate-panel:var(--surface);--plate-filter:none}}.hero__frame,.photo__frame{border-radius:var(--radius);background:var(--surface-2);isolation:isolate}.hero__frame:after,.photo__frame:after{content:"";pointer-events:none;border-radius:inherit;box-shadow:inset 0 0 0 1px var(--line);position:absolute;inset:0}.hero__img,.photo__img{filter:var(--photo-filter)}.media-credit{font-size:var(--s--2);color:var(--text-2)}.media-credit a{color:var(--text-2);text-underline-offset:.15em}.media-credit a:hover{color:var(--link)}.doc>.hero{margin-block:0 var(--space-6)}@media (min-width:64rem){.doc>.hero{margin-block:var(--space-2)var(--space-5)}}.hero__caption{padding-block-start:var(--space-3);padding-inline:var(--space-2)}.hero__text{font-size:var(--s--1);color:var(--text-2);max-inline-size:var(--measure);line-height:1.5}:is(.prose,.csec)>.photo{inline-size:min(100%,52rem);margin-block:var(--space-4)var(--space-7);grid-column:wide;justify-self:start}.photo__caption{padding-block-start:var(--space-3);padding-inline:var(--space-2);max-inline-size:var(--measure)}.photo__text{font-size:var(--s--1);color:var(--text-2);line-height:1.5}:is(.prose,.csec)>.plate,.plate{margin:var(--space-4)0 var(--space-7);padding:var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line);grid-column:wide}.plate__title{font-weight:600;font-size:var(--s-0);margin-block-end:var(--space-4)}.plate__art{border-radius:var(--radius-sm);background:var(--plate-panel);box-shadow:0 0 0 1px var(--line-strong);overflow:hidden}.plate__img{filter:var(--plate-filter)}.plate__marker{--tone:var(--text);--tone-ink:var(--ground);transform:scale(calc(1 + var(--on)*.22));transition:transform .45s var(--spring)}.plate__halo{fill:#0a0e14;opacity:.55}.plate__dot{fill:var(--tone);stroke:#0a0e14;stroke-width:1.5px;vector-effect:non-scaling-stroke}.plate__n{fill:var(--tone-ink);font-family:var(--font-sans)}.plate__marker:not([data-evidence]){--tone:#0b1220;--tone-ink:#fff}.plate__marker[data-evidence=demonstrated]{--tone:#00727c;--tone-ink:#fff}.plate__marker[data-evidence=hypothesis]{--tone:#8f5300;--tone-ink:#fff}:root[data-scheme=dark] .plate[data-dark-art] .plate__marker:not([data-evidence]){--tone:var(--text);--tone-ink:var(--ground)}:root[data-scheme=dark] .plate[data-dark-art] .plate__marker[data-evidence=demonstrated]{--tone:var(--cyan);--tone-ink:var(--cyan-ink)}:root[data-scheme=dark] .plate[data-dark-art] .plate__marker[data-evidence=hypothesis]{--tone:var(--amber);--tone-ink:var(--amber-ink)}@media (prefers-color-scheme:dark){:root:not([data-scheme=light]) .plate[data-dark-art] .plate__marker:not([data-evidence]){--tone:var(--text);--tone-ink:var(--ground)}:root:not([data-scheme=light]) .plate[data-dark-art] .plate__marker[data-evidence=demonstrated]{--tone:var(--cyan);--tone-ink:var(--cyan-ink)}:root:not([data-scheme=light]) .plate[data-dark-art] .plate__marker[data-evidence=hypothesis]{--tone:var(--amber);--tone-ink:var(--amber-ink)}}.plate__key-title{font-size:var(--s--1);color:var(--text-2);margin-block-end:var(--space-3);font-weight:600}.plate__item{padding:var(--space-3);border-radius:var(--radius-sm);transition:background .25s var(--ease)}.plate__item:hover{background:var(--surface-2)}.plate__num{--tone:var(--text-2);border:1.5px solid var(--tone);block-size:1.9rem;inline-size:1.9rem;color:var(--tone);font-weight:600;font-size:var(--s--1);transition:background .3s var(--ease),color .3s var(--ease);border-radius:50%}.plate__item[data-evidence=demonstrated] .plate__num{--tone:var(--cyan-text);--tone-ink:var(--cyan-ink)}.plate__item[data-evidence=hypothesis] .plate__num{--tone:var(--amber-text);--tone-ink:var(--amber-ink);border-style:dashed}.plate__item:hover .plate__num{background:var(--tone);color:var(--tone-ink,var(--ground))}.plate__label-text{font-weight:600}.plate__detail{font-size:var(--s--1);color:var(--text-2)}.plate__words{margin-block-start:var(--space-5)}.plate__words-summary{color:var(--link);font-size:var(--s--1)}.plate__words-text{font-size:var(--s--1);color:var(--text-2);max-inline-size:var(--measure);margin-block-start:var(--space-3)}.plate__sources,.plate__credit{font-size:var(--s--2);color:var(--text-2);margin-block-start:var(--space-3)}.plate__sources a{color:var(--text-2)}.plate__ref-n{font-size:max(.75em,.75rem)}.plate__credit{margin-block-start:var(--space-1)}.media-credits{margin-block-start:var(--space-8)}.media-credits__title{font-size:var(--s-3);letter-spacing:-.03em;margin-block-end:var(--space-5);font-weight:600;line-height:1.1}.media-credits__intro{color:var(--text-2);font-size:var(--s--1);margin-block-end:var(--space-3)}.media-credits ul.media-credits__list{margin-block-start:var(--space-5)}.media-credits__item{padding:var(--space-4);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line)}.media-credits__thumb{border-radius:var(--radius-sm);overflow:hidden}.media-credits__img{filter:var(--photo-filter)}.media-credits__shows{margin-block-end:var(--space-2)}.media-credits__kind{color:var(--text-2);font-weight:600}.media-credits__meta{font-size:var(--s--1);color:var(--text-2)}.media-credits__meta dt{color:var(--text-3)}.media-credits__review[data-review=pending]{border:1px dashed var(--text-3);border-radius:var(--radius-sm);color:var(--text-2);align-items:center;gap:.4em;padding:0 .45rem;display:inline-flex}.media-credits__review[data-review=pending]:before{content:"";block-size:1em;inline-size:1em;-webkit-mask:var(--glyph-pending)center/contain no-repeat;mask:var(--glyph-pending)center/contain no-repeat;background:currentColor;flex:none}.media-credits__review[data-review=ok]{color:var(--cyan-text)}.at-a-glance{min-inline-size:0}.at-a-glance__title{margin:0}.at-a-glance__tiles{grid-template-columns:minmax(0,1fr);margin:0;display:grid}.at-a-glance__tile{flex-direction:column;min-inline-size:0;display:flex}.at-a-glance__q{margin:0}.at-a-glance__a{align-items:flex-start;margin:0;display:flex}.at-a-glance__icon{flex:none;line-height:0;display:block}.at-a-glance__icon .pictogram{fill:currentColor;display:block}.at-a-glance__body{align-content:start;gap:var(--space-1);min-inline-size:0;display:grid}.at-a-glance__short,.at-a-glance__text,.at-a-glance__code{display:block}.at-a-glance__more{justify-self:start}.at-a-glance__foot{margin:0}.summary-box__head{align-items:center;gap:var(--space-2)var(--space-4);flex-wrap:wrap;display:flex}.summary-box__title{margin:0}.summary-box__time{align-items:center;gap:.5em;margin:0;display:flex}.summary-box__list{counter-reset:summary;margin:0;padding:0;list-style:none;display:grid}.summary-box__item{counter-increment:summary;grid-template-columns:auto minmax(0,1fr);align-items:start;display:grid}.summary-box__marker:before{content:counter(summary)}.summary-box__item:only-child{grid-template-columns:minmax(0,1fr)}.summary-box__item:only-child .summary-box__marker{display:none}:lang(ar) .summary-box__marker:before{content:counter(summary,arabic-indic)}.summary-box__text,.compound-tech{min-inline-size:0}.compound-tech__title{margin:0}.compound-tech .compound-facts{margin-block-start:0}@media (forced-colors:active){.at-a-glance__tile,.summary-box,.compound-tech{border:1px solid canvastext}.at-a-glance__icon .pictogram{fill:canvastext}}@media (max-width:29.99rem){.breadcrumbs,.site-main{padding-block-start:var(--space-3)}.doc-header{padding-block:var(--space-1)var(--space-3)}.doc-header .doc-header__lede{font-size:var(--s-0)}.doc-header__eyebrow{margin-block-end:var(--space-2)}.compound-badge{margin-block-start:var(--space-3)}.at-a-glance{margin-block-end:var(--space-4)}.at-a-glance .at-a-glance__tile{gap:.375rem}.doc>.notice{padding-block:var(--space-2);margin-block-end:var(--space-3)}}.doc>.at-a-glance{grid-column:wide}.at-a-glance{margin-block:0 var(--space-5)}.at-a-glance__title{font-size:var(--s-0);color:var(--text);margin-block-end:var(--space-2);font-weight:600}.at-a-glance__tiles{gap:var(--space-2)}@container doc (width>=36rem){.at-a-glance__tiles{gap:var(--space-3);grid-template-columns:repeat(2,minmax(0,1fr))}}.at-a-glance__tile{--tone:var(--text-2);--ring:1px solid var(--line-strong);--pg-cut:var(--surface-2);gap:var(--space-2);padding:var(--space-3)var(--space-4);border:1px solid var(--line);border-radius:var(--radius);background:var(--surface);transition:border-color .3s var(--ease)}.at-a-glance__tile[data-tone=yes]{--tone:var(--cyan);--ring:2px solid var(--cyan)}.at-a-glance__tile[data-tone=partial]{--tone:var(--text-2);--ring:1.5px solid var(--text-3)}.at-a-glance__tile[data-tone=no]{--tone:var(--text-2);--ring:1.5px dashed var(--text-3)}:is(.at-a-glance__tile:has(a):hover,.at-a-glance__tile:focus-within){border-color:var(--line-strong)}.at-a-glance__q{font-size:var(--s--1);color:var(--text-2);font-weight:500;line-height:1.35}.at-a-glance__a{gap:var(--space-3)}.at-a-glance__icon{background:var(--surface-2);border:var(--ring);block-size:2.5rem;inline-size:2.5rem;color:var(--tone);border-radius:50%;place-items:center;display:grid}.at-a-glance__icon .pictogram{block-size:1.6rem;inline-size:1.6rem}.at-a-glance__body{gap:.15rem}.at-a-glance__short{font-size:var(--s-1);letter-spacing:-.01em;color:var(--text);font-weight:600;line-height:1.2}.at-a-glance__text{color:var(--text);font-size:1.0625rem;line-height:1.45}.at-a-glance__text--risk{font-weight:500}.at-a-glance__code{font-size:var(--s--2);color:var(--text-2)}.at-a-glance__more{color:var(--link);font-size:var(--s--1);margin-block-start:var(--space-1)}.at-a-glance__more--signs{font-size:var(--s-0);font-weight:600}.at-a-glance__foot{font-size:var(--s--1);color:var(--text-2);margin-block-start:var(--space-2)}@container doc (width>=60rem){.at-a-glance__tiles{grid-template-columns:repeat(4,minmax(0,1fr))}.at-a-glance__a{align-items:center;gap:var(--space-2)var(--space-3);grid-template-columns:auto minmax(0,1fr);display:grid}.at-a-glance__body{display:contents}.at-a-glance__icon{grid-row:1}.at-a-glance__tile[data-q=risk] .at-a-glance__icon{align-self:start}.at-a-glance__text,.at-a-glance__code,.at-a-glance__more{grid-column:1/-1}.at-a-glance__short,.at-a-glance__text--risk,.at-a-glance__more--signs{grid-area:1/2}.at-a-glance__text--risk{font-size:var(--s-0);line-height:1.35}}.summary-box{padding:var(--space-5)var(--space-4);border:1px solid var(--line);border-radius:var(--radius);background:var(--surface);margin-block-end:var(--space-6)}@container doc (width>=40rem){.summary-box{padding-inline:var(--space-5)}}.summary-box__head{justify-content:space-between;align-items:baseline;margin-block-end:var(--space-4)}.summary-box__title{font-size:var(--s-2);letter-spacing:-.015em;color:var(--text);font-weight:600;line-height:1.15}.summary-box__time{font-size:var(--s--1);color:var(--text-2);align-items:flex-start}.summary-box__time:before{content:"";border:1.5px solid;border-radius:50%;flex:none;block-size:.55rem;inline-size:.55rem;margin-block-start:.5em}.summary-box__list{gap:var(--space-3);font-size:var(--s-1);line-height:1.5}.summary-box__item{column-gap:var(--space-3);position:relative}.summary-box__marker{z-index:1;border:1px solid var(--line-strong);background:var(--surface-2);block-size:1.9rem;inline-size:1.9rem;font-family:var(--font-mono);font-size:var(--s--2);font-variant-numeric:tabular-nums;color:var(--text);border-radius:50%;place-items:center;margin-block-start:.05rem;font-weight:600;display:grid;position:relative}.summary-box__item:not(:last-child):after{content:"";inset-block:1.95rem calc(-1*var(--space-3));border-inline-start:1px solid var(--line-strong);position:absolute;inset-inline-start:calc(.95rem - .5px)}.summary-box__text{color:var(--text)}@media (max-width:29.99rem){.summary-box{padding-block-start:var(--space-4)}.summary-box__head{margin-block-end:var(--space-3)}.summary-box__list{font-size:var(--s-0)}}.compound-tech{padding:var(--space-5);border:1px solid var(--line);border-radius:var(--radius);background:var(--surface)}.compound-tech__title{font-size:var(--s-1);letter-spacing:-.015em;margin-block-end:var(--space-4);font-weight:600}.compound-tech .compound-facts>div{background:var(--ground)}.explainer{--xp-step:calc(var(--xp-dur,12s)/var(--xp-steps,5));--xp-in-dur:.8s;--xp-ease:ease-out;margin-block:0 var(--space-6,2rem);min-inline-size:0;container:xp/inline-size}.xp-head{gap:.15rem;margin-block-end:var(--space-4,1rem);display:grid}.xp-body{gap:var(--space-4,1rem);display:grid}@container xp (width>=44rem){.xp-body{align-items:start;gap:var(--space-5,1.5rem);grid-template-columns:minmax(0,7fr) minmax(0,5fr)}}.xp-visual{gap:var(--space-3,.75rem);align-content:start;min-inline-size:0;display:grid;position:relative}.xp-stage{--xp-sx:1;direction:ltr}.xp-canvas{position:relative;container-type:inline-size}[dir=rtl] .explainer[data-mirror] .xp-stage{--xp-sx:-1;direction:rtl}[dir=rtl] .explainer[data-mirror] .xp-art{scale:-1 1}.xp-art{block-size:auto;inline-size:100%;display:block;overflow:visible}.explainer{--xp-ground:Canvas}.explainer[data-backdrop] .xp-stage{padding:0}.xp-canvas[data-backdrop]>.xp-art{position:relative}.xp-backdrop{display:block;position:absolute;inset:0}.xp-canvas .xp-backdrop--light{display:var(--plate-show-light,block)}.xp-canvas .xp-backdrop--dark{display:var(--plate-show-dark,none)}.xp-backdrop__img{object-fit:cover;block-size:100%;inline-size:100%;display:block}.explainer[data-backdrop] .xp-label__in{background:color-mix(in srgb,var(--xp-ground)84%,transparent);padding-inline:.2em;display:inline-block}.explainer[data-backdrop] .xp-label{overflow-wrap:normal}.xp-art .xp-halo.xp-halo{fill:none;stroke:var(--xp-ground);stroke-width:var(--xp-halo-w,5);stroke-linecap:round;stroke-linejoin:round;opacity:.85}.xp-art .xp-veil{fill:var(--xp-ground);fill-rule:evenodd;visibility:hidden;opacity:0}.xp-pin,.xp-label{pointer-events:none;position:absolute;inset-block-start:var(--y);inset-inline-start:var(--x)}.xp-pin{translate:calc(-50%*var(--xp-sx))-50%;font-variant-numeric:tabular-nums;place-items:center;block-size:1.7em;min-inline-size:1.7em;padding-inline:.25em;font-size:clamp(.72rem,2.9cqi,.95rem);font-weight:700;line-height:1;display:grid}.xp-label{--ax:0%;--ay:0%;translate:calc(var(--ax)*var(--xp-sx))var(--ay);inline-size:max-content;max-inline-size:var(--mw,34%);overflow-wrap:anywhere;font-size:clamp(.72rem,2.8cqi,.95rem);line-height:1.15}.xp-label bdi{white-space:pre-line}.xp-label[data-align=center]{--ax:-50%;text-align:center}.xp-label[data-align=end]{--ax:-100%;text-align:end}.xp-label[data-valign=middle]{--ay:-50%}.xp-label[data-valign=bottom]{--ay:-100%}.xp-lico{vertical-align:-.2em;block-size:1.15em;inline-size:1.15em;margin-inline-end:.2em;display:inline-block;overflow:visible}.xp-lico__line,.xp-lico__mark{fill:none;stroke:currentColor;stroke-width:2.2px;stroke-linecap:round;stroke-linejoin:round}.xp-lico__fill,.xp-lico__dot{fill:currentColor}.xp-panels{gap:var(--space-4,1rem)var(--space-4,1rem);display:grid}@container (width>=34rem){.xp-panels{grid-template-columns:repeat(var(--xp-cols,2),minmax(0,1fr))}}.xp-panel{grid-row:span 2;grid-template-rows:subgrid;row-gap:var(--space-1,.25rem);min-inline-size:0;display:grid}.xp-panel__title{align-self:end;margin:0}.xp-panel__art{position:relative;container-type:inline-size}.xp-panel__art .xp-label{font-size:clamp(.875rem,4.4cqi,1.0625rem)}.xp-art :is(.xp-link,.xp-curve,.xp-arrow,.xp-detail,.xp-rec,.xp-tail,.xp-axis,.xp-open,.xp-hatch,.xp-warn-mark){fill:none;stroke-linecap:round;stroke-linejoin:round}.xp-link[data-level=animal],.xp-link[data-level=in-vitro]{stroke-dasharray:8 5}.xp-link[data-level=hypothesis]{stroke-dasharray:2 5}.xp-ring[data-level=animal],.xp-ring[data-level=in-vitro]{stroke-dasharray:7 5}.xp-ring[data-level=hypothesis]{stroke-dasharray:2 5}.xp-link[data-level=human],.xp-curve{--xp-in:var(--xp-draw,xp-draw)}.xp-link:not([data-level=human]){--xp-in:var(--xp-dashed-in,xp-fade);--xp-ease:var(--xp-dashed-ease,ease-out)}.xp-move{--xp-in:var(--xp-move,xp-move)}.explainer .xp-flow{--xp-in:var(--xp-flow,xp-flow);--xp-in-dur:calc(var(--xp-step)*.8);--xp-ease:var(--xp-flow-ease,linear)}.xp-in,.xp-out,.xp-shrink,.xp-pulse{transform-box:fill-box;transform-origin:50%}.xp-out{opacity:0}.xp-shrink{scale:var(--s,.6)}.xp-ghost{opacity:var(--xp-ghost,.4)}.xp-danger-hot{opacity:1}.xp-controls{align-items:center;gap:var(--space-2,.5rem)var(--space-3,.75rem);flex-wrap:wrap;display:none}:root.js .xp-controls{display:flex}.explainer:not(.is-live) .xp-controls{visibility:hidden}.xp-btn{font:inherit;cursor:pointer;align-items:center;gap:.45em;display:inline-flex}.xp-ico{fill:currentColor;flex:none;block-size:1em;inline-size:1em}.xp-btn--toggle{max-inline-size:100%;display:inline-grid}.xp-btn__face{visibility:hidden;grid-area:1/1;justify-content:center;align-items:center;gap:.45em;display:inline-flex}.xp-btn--toggle:is([data-state=idle],:not([data-state]))>[data-face=idle],.xp-btn--toggle[data-state=playing]>[data-face=playing],.xp-btn--toggle[data-state=paused]>[data-face=paused],.xp-btn--toggle[data-state=ended]>[data-face=ended]{visibility:visible}.xp-progress{flex:3rem;gap:3px;min-inline-size:2.5rem;display:flex}.xp-seg{flex:1 1 0;position:relative;overflow:hidden}.xp-seg:before{content:"";transform-origin:0;position:absolute;inset:0}[dir=rtl] .xp-seg:before{transform-origin:100%}.xp-clock{block-size:0;inline-size:0;position:absolute;overflow:hidden}.xp-rm-note{margin:0;display:none}.xp-now{display:grid}.xp-now>p{grid-area:1/1;margin:0}.xp-now__step{display:none}@media (prefers-reduced-motion:no-preference){:root.js .xp-now__step{visibility:hidden;display:block}}.xp-now__n{font-variant-numeric:tabular-nums}.xp-text{min-inline-size:0}.xp-steps{margin:0;padding:0;list-style:none;display:grid}.xp-step{border-inline-start:3px solid #0000;grid-template-columns:auto minmax(0,1fr);align-items:start;display:grid}.xp-step__text,.xp-step__levels{margin:0}.xp-step__levels{flex-wrap:wrap;gap:.3em;display:flex}.xp-summary,.xp-legend,.xp-sources{margin-block:var(--space-3,.75rem)0;margin-inline:0}.xp-credit{margin-block:var(--space-1,.25rem)0;margin-inline:0}.xp-legend{flex-wrap:wrap;align-items:center;gap:.25em .9em;display:flex}.xp-key{align-items:center;gap:.4em;display:inline-flex}.xp-key__line{flex:none;block-size:.5em;inline-size:2em;overflow:visible}.explainer.is-playing :is(.xp-in,.xp-pin){animation:var(--xp-in,xp-fade)var(--xp-in-dur)var(--xp-ease)calc(var(--k,0)*var(--xp-step) + var(--lag,0s))1 both}.explainer.is-playing .xp-pin{--xp-in:var(--xp-pin-in,xp-fade)}.explainer.is-playing .xp-out{animation:xp-out var(--xp-in-dur)ease-in calc(var(--k,0)*var(--xp-step) + var(--lag,0s))1 both}.explainer.is-playing .xp-shrink{animation:xp-shrink var(--xp-in-dur)var(--xp-ease)calc(var(--k,0)*var(--xp-step) + var(--lag,0s))1 both}.explainer.is-playing .xp-ghost{animation:xp-ghost var(--xp-in-dur)ease-in-out calc(var(--k,0)*var(--xp-step) + var(--lag,0s))1 both}.explainer.is-playing .xp-pulse{animation:var(--xp-pulse,xp-pulse)calc(var(--xp-step)*.6)ease-in-out calc(var(--k,0)*var(--xp-step) + var(--lag,0s))1 none}.explainer.is-playing .xp-step{animation:xp-current var(--xp-step)linear calc(var(--k,0)*var(--xp-step))1 none}.explainer.is-playing .xp-step__n{animation:xp-current-n var(--xp-step)linear calc(var(--k,0)*var(--xp-step))1 none}.explainer.is-playing .xp-seg:before{animation:xp-fill var(--xp-step)linear calc(var(--k,0)*var(--xp-step))1 both}.explainer.is-playing .xp-clock{animation:xp-clock var(--xp-dur)linear 1 both}.explainer.is-playing .xp-focus{opacity:var(--xp-dim,.3);animation:xp-lit calc(var(--span,1)*var(--xp-step))linear calc(var(--k,0)*var(--xp-step))1 none}:is(.xp-label,.xp-panel__title) .xp-focus,.xp-panel__title.xp-focus{--xp-dim:var(--xp-dim-text,.5)}.explainer.is-playing .xp-veil{animation:xp-veil calc(var(--span,1)*var(--xp-step))linear calc(var(--k,0)*var(--xp-step))1 none}.explainer.is-playing .xp-now__still{visibility:hidden}.explainer.is-playing .xp-now__step{animation:var(--xp-now,xp-now)var(--xp-step)linear calc(var(--k,0)*var(--xp-step))1 none}.explainer.is-paused,.explainer.is-paused *,.explainer.is-paused :before,.explainer.is-paused :after{animation-play-state:paused!important}@keyframes xp-fade{0%{opacity:0}to{opacity:1}}@keyframes xp-pop{0%{opacity:0;scale:.3}to{opacity:1;scale:1}}@keyframes xp-draw{0%{stroke-dasharray:1 2;stroke-dashoffset:1.01px}to{stroke-dasharray:1 2;stroke-dashoffset:0}}@keyframes xp-move{0%{opacity:0;translate:var(--dx,0px)var(--dy,0px)}to{opacity:1;translate:0}}@keyframes xp-flow{0%{opacity:0;translate:var(--dx,-40px)0}18%{opacity:1}to{opacity:1;translate:0}}@keyframes xp-veil{0%{visibility:visible;opacity:0}7%,93%{visibility:visible;opacity:var(--xp-veil,.62)}to{visibility:visible;opacity:0}}@keyframes xp-out{0%{opacity:1}to{opacity:0}}@keyframes xp-shrink{0%{scale:1}to{scale:var(--s,.6)}}@keyframes xp-ghost{0%{opacity:1}to{opacity:var(--xp-ghost,.4)}}@keyframes xp-pulse{0%,to{scale:1}50%{scale:1.18}}@keyframes xp-current{0%,to{background-color:var(--xp-cur-bg,transparent);border-inline-start-color:var(--xp-cur-line,currentColor)}}@keyframes xp-current-n{0%,to{color:var(--xp-cur-n-ink,currentColor);background-color:var(--xp-cur-n-bg,transparent)}}@keyframes xp-fill{0%{scale:0 1}to{scale:1}}@keyframes xp-clock{0%{opacity:0}to{opacity:0}}@keyframes xp-lit{0%,to{opacity:var(--xp-dim,.3)}8%,92%{opacity:1}}@keyframes xp-now{0%{visibility:visible;opacity:0}6%,to{visibility:visible;opacity:1}}@keyframes xp-now-cut{0%,to{visibility:visible}}@media (prefers-reduced-motion:reduce){.explainer *,.explainer :before,.explainer :after{animation:none!important}.explainer .xp-controls{display:none!important}.explainer .xp-rm-note{display:block}}@media print{.explainer .xp-controls,.explainer .xp-rm-note,.explainer .xp-now__step{display:none!important}.xp-canvas .xp-backdrop--light{display:block}.xp-canvas .xp-backdrop--dark{display:none}.explainer *,.explainer :before,.explainer :after{animation:none!important}}@media (forced-colors:active){.xp-art :is(.xp-link,.xp-curve,.xp-arrow,.xp-organ,.xp-cell,.xp-axis,.xp-ring,.xp-plate){stroke:canvastext}.xp-art :is(.xp-drug,.xp-hot,.xp-warn){fill:highlight}.xp-pin{forced-color-adjust:none;color:canvastext;background:canvas;border:1px solid canvastext}.xp-art .xp-halo.xp-halo{stroke:canvas}.xp-art .xp-veil{display:none}.xp-step{border-inline-start-color:#0000}}.explainer{--xp-in-dur:1.1s;--xp-ease:var(--spring);--xp-move:xp-move;--xp-pin-in:xp-pop;--xp-dashed-ease:var(--ease);--xp-ghost:.3;--xp-dim:.25;--xp-cur-bg:var(--surface-2);--xp-cur-n-ink:var(--text);--xp-cur-n-bg:transparent;margin-block:var(--space-4)var(--space-7);padding:var(--space-5);border-radius:var(--radius);background:var(--surface);border:1px solid var(--line)}:is(.prose,.csec)>.explainer{grid-column:wide}.xp-kicker{font-size:var(--s--2);color:var(--text-2);font-weight:600}.xp-title{font-size:var(--s-1);letter-spacing:-.015em;color:var(--text);font-weight:600;line-height:1.25}.xp-stage{padding:var(--space-3);border-radius:var(--radius-sm);border:1px solid var(--line);background:var(--ground)}.xp-stage .xp-label{font-size:clamp(.875rem,2.8cqi,1rem)}.xp-stage .xp-pin{font-size:clamp(.75rem,2.9cqi,.95rem)}@media (max-width:30rem){.explainer{padding:var(--space-3)}.xp-stage{padding:var(--space-2)}}.explainer{--xp-ground:var(--ground);--xp-halo-w:6;--xp-veil:.62}.explainer[data-backdrop] .xp-stage{background:var(--ground);overflow:hidden}.xp-art :is(.xp-link[data-level=human],.xp-curve){--xp-ease:var(--ease)}.xp-art .xp-vessel{fill:color-mix(in oklch,var(--res-positive)9%,var(--surface));stroke:color-mix(in oklch,var(--res-positive)40%,var(--line));stroke-width:1.2px}.xp-art .xp-organ{fill:var(--surface-2);stroke:var(--line-strong);stroke-width:1.6px}.xp-art .xp-open{fill:none}.xp-art .xp-cell{fill:var(--surface);stroke:var(--text-3);stroke-width:1.4px}.xp-art .xp-rec{stroke:var(--res-aromatic);stroke-width:1.8px}.xp-art .xp-ring{fill:none;stroke:var(--res-aromatic);stroke-width:1.6px}.xp-art .xp-alb{fill:var(--res-special);fill-opacity:.55}.xp-art .xp-drug{fill:var(--res-hydrophobic)}.xp-art .xp-tail{stroke:var(--res-hydrophobic);stroke-width:2px}.xp-art .xp-glu{fill:var(--res-polar)}.xp-art .xp-ins{fill:var(--res-aromatic)}.xp-art .xp-gcg{fill:var(--res-positive)}.xp-art .xp-food{fill:color-mix(in oklch,var(--res-nonstandard)28%,var(--surface-2))}.xp-art .xp-plate{fill:var(--surface);stroke:var(--line-strong);stroke-width:1.4px}.xp-art .xp-detail{stroke:var(--line-strong);stroke-width:1px}.xp-art .xp-inset{fill:var(--ground);stroke:var(--line-strong);stroke-width:1px}.xp-art .xp-hot{fill:var(--cyan)}.xp-art .xp-arrow{stroke:var(--text);stroke-width:2px}.xp-art .xp-link,.xp-key .xp-link{stroke:var(--cyan);stroke-width:2.6px}.xp-art .xp-link[data-level=hypothesis],.xp-key .xp-link[data-level=hypothesis]{stroke:var(--amber)}.xp-key .xp-link{stroke-width:2.2px}.xp-art .xp-zone{fill:color-mix(in oklch,var(--res-polar)11%,transparent)}.xp-art .xp-danger{fill:color-mix(in oklch,var(--alert)10%,transparent)}.xp-art .xp-danger-hot{fill:color-mix(in oklch,var(--alert)16%,transparent);stroke:var(--alert);stroke-width:1.2px}.xp-art .xp-axis{stroke:var(--text-3);stroke-width:1.4px}.xp-art .xp-curve{stroke:var(--text);stroke-width:3px}.xp-art .xp-curve--safe{stroke:var(--res-polar)}.xp-art .xp-su{fill:var(--res-negative)}.xp-art .xp-arrow--push{stroke:var(--res-negative)}.xp-art .xp-warn{fill:var(--alert)}.xp-art .xp-warn-mark{stroke:var(--ground);stroke-width:2.6px}.xp-art .xp-warn-dot{fill:var(--ground)}.xp-art .xp-sugar{fill:var(--res-nonstandard)}.xp-art .xp-arrow--up{stroke:var(--res-polar)}.xp-art .xp-germ{fill:var(--res-hydrophobic);stroke:var(--xp-ground);stroke-width:1.5px}.xp-art .xp-redness{fill:color-mix(in oklch,var(--res-negative)30%,transparent);stroke:var(--res-negative);stroke-width:2px}.xp-art .xp-curve.xp-redline{stroke:var(--res-negative);stroke-width:5px}.xp-art .xp-halo.xp-halo.xp-redline{stroke:var(--xp-ground);stroke-width:9px}.xp-art .xp-pus{fill:var(--surface);fill-opacity:.85}:root[data-scheme=dark] .xp-art .xp-pus{fill:var(--text);fill-opacity:.72}@media (prefers-color-scheme:dark){:root:not([data-scheme=light]) .xp-art .xp-pus{fill:var(--text);fill-opacity:.72}}.xp-art .xp-cup{fill:none;stroke:var(--res-aromatic);stroke-width:4px;stroke-linecap:round;stroke-linejoin:round}.xp-pin{border-radius:var(--radius-pill);background:var(--text);color:var(--ground);font-family:var(--font-mono);box-shadow:0 0 0 3px var(--ground)}.xp-label{letter-spacing:.01em;color:var(--text-2);font-weight:500}.xp-label[data-tone=note]{color:var(--text);font-weight:600}.xp-lico[data-icon=check]{color:var(--res-polar)}.xp-lico[data-icon=warn]{color:var(--alert)}.xp-lico[data-icon=warn] :is(.xp-lico__mark,.xp-lico__dot){stroke:var(--ground);fill:var(--ground)}.xp-lico[data-icon=warn] .xp-lico__mark{stroke-width:2px}.xp-lico[data-icon=sugar]{color:var(--surface)}.xp-lico[data-icon=sugar] .xp-lico__fill{fill:var(--res-nonstandard)}.xp-lico[data-icon=sugar] .xp-lico__line{stroke-width:1.2px}.xp-panel__title{font-size:var(--s--1);color:var(--text);font-weight:600;line-height:1.3}.xp-now>p{font-size:var(--s-0);color:var(--text);line-height:1.45}.xp-now__n{background:var(--text);block-size:1.6em;min-inline-size:1.6em;color:var(--ground);font-family:var(--font-mono);font-size:var(--s--1);vertical-align:.05em;border-radius:50%;place-items:center;margin-inline-end:.4em;font-weight:700;display:inline-grid}.xp-btn{border-radius:var(--radius);border:1px solid var(--line-strong);background:var(--surface-2);min-block-size:2.5rem;color:var(--text);font-size:var(--s--1);transition:border-color .3s var(--ease),background-color .3s var(--ease);padding:.35rem 1rem;font-weight:600}.xp-btn:hover{border-color:var(--link)}.xp-btn--toggle{background:color-mix(in oklch,var(--link)16%,var(--surface-2));border-color:color-mix(in oklch,var(--link)50%,var(--line))}.xp-progress{block-size:4px}.xp-seg{background:var(--line);border-radius:2px}.xp-seg:before{background:var(--link);border-radius:2px}.xp-rm-note{font-size:var(--s--2);color:var(--text-2)}.xp-steps{gap:var(--space-2)}.xp-step{--xp-cur-line:var(--cyan);gap:0 var(--space-3);padding:var(--space-3)var(--space-4);border-radius:var(--radius-sm);border:1px solid var(--line);border-inline-start:3px solid var(--cyan)}.xp-step[data-level=animal],.xp-step[data-level=in-vitro]{border-inline-start-style:dashed}.xp-step .level-badge[data-level=in-vitro]:before{border-block-start-style:dashed}.xp-step[data-level=hypothesis]{--xp-cur-line:var(--amber);border-inline-start-color:var(--amber);border-inline-start-style:dotted}.xp-step__n{font-family:var(--font-mono);color:var(--text-2);padding-block-start:.1em;font-weight:700}.xp-step__text{font-size:var(--s--1);color:var(--text);line-height:1.55}.xp-step__levels{font-size:var(--s--2);margin-block-start:var(--space-2)}.xp-summary{font-size:var(--s--1);color:var(--text-2)}.xp-legend{font-size:var(--s--2);color:var(--text-2)}.xp-legend__title{color:var(--text-2);font-weight:600}.xp-sources,.xp-credit{font-size:var(--s--2);color:var(--text-2)}.xp-sources__label{color:var(--text-2);font-weight:600}.doc-header__lede{margin:var(--space-3)0 0;font-size:var(--fig-lede);text-wrap:pretty;max-inline-size:38ch;line-height:1.35}.lead{gap:var(--space-1);margin-block:0 var(--space-5);display:grid}.lead__q{color:var(--fig-ink-2);margin:0;font-weight:600}.lead__a{font-size:var(--fig-lede);text-wrap:pretty;max-inline-size:40ch;line-height:1.35}.lead__a>*{margin:0}.in-detail{border-block-end:1px solid var(--fig-line);margin:0}:is(.csec,.in-detail__body,.prose,.compound-glance,.grade,.source-list)>.in-detail:not(.in-detail+.in-detail){border-block-start:1px solid var(--fig-line)}.in-detail+:not(.in-detail){margin-block-start:var(--space-5)}.in-detail__summary{align-items:baseline;gap:var(--space-3);min-block-size:2.75rem;padding-block:var(--space-3);cursor:pointer;grid-template-columns:auto minmax(0,1fr) auto;list-style:none;display:grid}.in-detail__summary::-webkit-details-marker{display:none}.in-detail__icon{border:1px solid var(--fig-ink);border-radius:var(--fig-radius);align-self:center;place-items:center;block-size:1.1rem;inline-size:1.1rem;display:grid}.in-detail__icon:before,.in-detail__icon:after{content:"";background:var(--fig-ink);grid-area:1/1;block-size:1.5px;inline-size:.6rem}.in-detail__icon:after{rotate:90deg}.in-detail[open]>.in-detail__summary .in-detail__icon:after{display:none}.in-detail__head{flex-wrap:wrap;align-items:baseline;gap:0 .5em;min-inline-size:0;display:flex;position:relative}.in-detail__label{font-size:var(--fig-tiny);color:var(--fig-ink-3)}.in-detail+.in-detail>.in-detail__summary .in-detail__label{clip-path:inset(50%);white-space:nowrap;block-size:1px;inline-size:1px;position:absolute;overflow:hidden}.in-detail__title{font-weight:600}.in-detail__time{font-size:var(--fig-tiny);color:var(--fig-ink-3);white-space:nowrap}.in-detail__summary:hover .in-detail__title{text-underline-offset:.2em;text-decoration:underline;text-decoration-thickness:1px}.in-detail__body{padding-block:var(--space-2)var(--space-5);min-inline-size:0}.in-detail__body>:last-child{margin-block-end:0}.reading-tools{justify-content:space-between;align-items:center;gap:var(--space-2)var(--space-4);margin-block:0 var(--space-5);flex-wrap:wrap;display:flex}.reading-tools__text{font-size:var(--fig-small);color:var(--fig-ink-2);max-inline-size:46ch;margin:0}.reading-tools__toggle{min-block-size:2.75rem;font:inherit;color:var(--fig-ink);background:var(--fig-paper);border:1px solid var(--fig-ink);border-radius:var(--fig-radius);cursor:pointer;align-items:center;gap:.5em;padding:.4rem .9rem;font-weight:600;display:inline-flex}.reading-tools__icon{place-items:center;block-size:.9rem;inline-size:.9rem;display:grid}.reading-tools__icon:before,.reading-tools__icon:after{content:"";background:currentColor;grid-area:1/1;block-size:2px;inline-size:.9rem}.reading-tools__icon:after{rotate:90deg}.reading-tools__toggle[data-state=open] .reading-tools__icon:after{display:none}.reading-tools__nojs{cursor:pointer;align-items:center;gap:.5em;min-block-size:2.75rem;font-weight:600;display:inline-flex}.reading-tools__check{block-size:1.25rem;inline-size:1.25rem;accent-color:var(--fig-accent);margin:0}:root:not(.js) .reading-tools__toggle,:root.js .reading-tools__nojs{display:none}@supports not selector(::details-content){.reading-tools__nojs{display:none}}@supports selector(::details-content){:root:not(.js):has(.reading-tools__check:checked) .in-detail::details-content{content-visibility:visible;block-size:auto;display:block}}.stop-strip{--pg-cut:var(--fig-alert-tint);margin-block:0 var(--space-6);padding:var(--space-4)var(--space-5);background:var(--fig-alert-tint);border-inline-start:4px solid var(--fig-alert);border-radius:var(--fig-radius)}.stop-strip__title{margin:0 0 var(--space-3);color:var(--fig-alert);font-size:var(--s-1);align-items:center;gap:.45em;font-weight:700;line-height:1.2;display:flex}.stop-strip__glyph{flex:none;block-size:1.1em;inline-size:1.1em}.stop-strip__list{gap:var(--space-3)var(--space-5);grid-template-columns:repeat(auto-fit,minmax(min(100%,14rem),1fr));margin:0;padding:0;list-style:none;display:grid}.stop-strip__item{align-items:center;gap:var(--space-3);min-inline-size:0;display:flex}.stop-strip__icon{color:var(--fig-alert);flex:none;line-height:0}.stop-strip__icon .pictogram{fill:currentColor;block-size:2.75rem;inline-size:2.75rem;display:block}.stop-strip__text{color:var(--fig-ink);font-weight:600;line-height:1.35}.stop-strip__foot{justify-content:space-between;align-items:center;gap:var(--space-2)var(--space-5);border-block-start:1px solid var(--fig-alert);flex-wrap:wrap;margin-block-start:var(--space-4);padding-block-start:var(--space-3);display:flex}.stop-strip__call{align-items:center;gap:var(--space-2);color:var(--fig-alert);margin:0;display:flex}.stop-strip__call-icon{flex:none;line-height:0}.stop-strip__call-icon .pictogram{fill:currentColor;block-size:1.75rem;inline-size:1.75rem;display:block}.stop-strip__links{gap:var(--space-1)var(--space-4);flex-wrap:wrap;margin:0;display:flex}.stop-strip__links a{color:var(--fig-ink);font-weight:600}.fact-sheet{min-inline-size:0;margin-block:0 var(--space-5)}.fact-sheet__list{border-block-start:1px solid var(--fig-line);grid-template-columns:minmax(0,1fr);margin:0;display:grid}.fact-sheet__row{column-gap:var(--space-4);padding-block:var(--space-2);border-block-end:1px solid var(--fig-line);grid-template-columns:minmax(7rem,2fr) minmax(0,3fr);display:grid}.fact-sheet__row dt{color:var(--fig-ink-3);font-size:var(--fig-small)}.fact-sheet__row dd{font-size:var(--fig-small);margin:0;font-weight:600}.fact-sheet__note{margin:var(--space-2)0 0;font-size:var(--fig-tiny);color:var(--fig-ink-2)}.doc,.prose>:first-child{counter-reset:fig}ul:is(.time-strip__rows,.icon-array__rows,.stop-strip__list){margin:0;padding:0;list-style:none}p.time-strip__text{max-inline-size:none}li:is(.time-strip__row,.icon-array__row,.stop-strip__item){max-inline-size:none;margin:0}.fig{counter-increment:fig;margin:0 0 var(--space-6);min-inline-size:0}.fig__head{gap:var(--space-1);margin-block-end:var(--space-4);display:grid}.fig__label{font-size:var(--fig-tiny);color:var(--fig-ink-3)}.fig__label:after{content:" " counter(fig)}.fig__title{text-wrap:pretty;max-inline-size:52ch;font-weight:600;line-height:1.3}.fig__detail{font-size:var(--fig-small);color:var(--fig-ink-2);max-inline-size:62ch}.fig__card{gap:var(--space-1)var(--space-4);margin:var(--space-3)0 0;border-block-start:1px solid var(--fig-line);font-size:var(--fig-tiny);color:var(--fig-ink-2);flex-wrap:wrap;padding-block-start:var(--space-2);display:flex}.fig__field{min-inline-size:0}.fig__key{color:var(--fig-ink-3)}.key-numbers{gap:var(--space-5)var(--gap,var(--space-5));margin-block:0 var(--space-6);grid-template-columns:repeat(auto-fit,minmax(min(100%,15rem),1fr));display:grid}@media (min-width:40rem){.key-numbers--4{grid-template-columns:repeat(2,minmax(0,1fr))}}.key-number{align-content:start;gap:var(--space-1);margin:0 0 var(--space-5);min-inline-size:0;border-block-start:2px solid var(--fig-ink);padding-block-start:var(--space-3);display:grid}.key-numbers>.key-number{margin:0}.key-number__title{margin:0;font-weight:600;line-height:1.3}.key-number__value{letter-spacing:-.02em;color:var(--fig-accent);font-variant-numeric:tabular-nums;margin:0;font-size:clamp(2.25rem,1.9rem + 1.4vw,3rem);font-weight:600;line-height:1.05}.key-number__unit{font-size:var(--s-0);letter-spacing:0;font-weight:400}.key-number__label{font-size:var(--fig-small);color:var(--fig-ink-2);max-inline-size:40ch;margin:0;line-height:1.45}.key-number .fig__card{margin-block-start:var(--space-2)}.compare__table{container:compare/inline-size}.compare table{border-collapse:collapse;inline-size:100%}.compare :is(th,td){padding-block:var(--space-3);padding-inline:0 var(--space-4);text-align:start;vertical-align:top;border-block-end:1px solid var(--fig-line)}.compare thead th{font-weight:600;font-size:var(--fig-small);color:var(--fig-ink-2);border-block-end:2px solid var(--fig-ink)}.compare tbody th{font-weight:600}.compare td{font-size:var(--fig-small);line-height:1.4}.compare td>.verdict{font-size:var(--s-0);margin-block-end:.2rem;display:flex}.verdict{white-space:nowrap;align-items:center;gap:.4em;margin-inline-end:.3em;display:inline-flex}.verdict__glyph{flex:none;block-size:1.2em;inline-size:1.2em;overflow:visible}.verdict__box{fill:none;stroke:var(--fig-ink);stroke-width:1.5px}.verdict__mark{fill:none;stroke:var(--fig-ink);stroke-width:2.2px;stroke-linecap:round;stroke-linejoin:round}.verdict[data-verdict=yes] .verdict__box{fill:var(--fig-ink)}.verdict__hatch{fill:none;stroke:var(--fig-ink-3);stroke-width:1px}.verdict__clear{fill:var(--fig-paper)}.verdict__word{font-weight:700}@container compare (width<=38rem){.compare table,.compare tbody,.compare tr{display:block}.compare thead{clip-path:inset(50%);white-space:nowrap;block-size:1px;inline-size:1px;position:absolute;overflow:hidden}.compare tr{padding-block:var(--space-3);border-block-end:1px solid var(--fig-line)}.compare tbody tr:first-child{border-block-start:2px solid var(--fig-ink)}.compare tbody th{padding:0 0 var(--space-2);font-size:var(--s-0);border:0;display:block}.compare td{padding-block:var(--space-2);border:0;padding-inline:0;display:block}.compare td:before{content:attr(data-label);font-size:var(--fig-tiny);color:var(--fig-ink-3);margin-block-end:.15rem;display:block}}.icon-array__rows{gap:var(--space-5)var(--space-6);grid-template-columns:repeat(auto-fill,minmax(min(100%,16rem),1fr));margin:0;padding:0;list-style:none;display:grid}.icon-array__row{gap:var(--space-2);min-inline-size:0;display:grid}.icon-array__label{margin:0;font-weight:600}.icon-array__pair{gap:var(--space-3)var(--space-5);flex-wrap:wrap;display:flex}.icon-array__cell{gap:var(--space-1);justify-items:start;display:grid}.icon-array__grid{direction:ltr;block-size:6.125rem;inline-size:6.125rem;display:block}.icon-array__sq{fill:var(--fig-paper);stroke:var(--fig-ink-3);stroke-width:1px}.icon-array__sq.is-on{fill:var(--fig-accent);stroke:var(--fig-accent)}.icon-array__cell[data-group=b] .icon-array__sq.is-on{fill:var(--fig-ink-2);stroke:var(--fig-ink-2)}.icon-array__n{font-size:var(--fig-small);margin:0;line-height:1.3}.icon-array__count{font-variant-numeric:tabular-nums;display:block}.icon-array__group{color:var(--fig-ink-2)}.time-strip__rows{gap:var(--space-4);margin:0;padding:0;list-style:none;display:grid}.time-strip__row{gap:var(--space-1);min-inline-size:0;display:grid}.time-strip__label{font-weight:600;font-size:var(--fig-small);margin:0;line-height:1.35}.time-strip__track{border-block-end:1px solid var(--fig-line);block-size:.875rem;position:relative}.time-strip__bar{inline-size:max(3px,calc((var(--to) - var(--from))*100%));background:var(--fig-accent);position:absolute;inset-block:0;inset-inline-start:calc(var(--from)*100%)}.time-strip__bar.is-unknown{background:repeating-linear-gradient(-45deg,var(--fig-ink-3)0 1px,transparent 1px 6px);outline:1px solid var(--fig-ink-3);outline-offset:-1px}.time-strip__text{max-inline-size:none;font-size:var(--fig-small);color:var(--fig-ink-2);margin:0;padding-inline-start:calc(var(--from)*100%);line-height:1.35}.time-strip__text.is-end{text-align:end;padding-inline-start:0}.time-strip__unknown{color:var(--fig-ink);font-weight:600}.time-strip__axis{block-size:1.75rem;border-block-start:1px solid var(--fig-ink);margin-block-start:var(--space-3);position:relative}.time-strip__tick{inline-size:0;font-size:var(--fig-tiny);color:var(--fig-ink-2);white-space:nowrap;justify-content:center;padding-block-start:.4rem;display:flex;position:absolute;inset-block-start:0;inset-inline-start:calc(var(--at)*100%)}.time-strip__tick:before{content:"";border-inline-start:1px solid var(--fig-ink);block-size:.3rem;position:absolute;inset-block-start:-1px;inset-inline-start:0}.time-strip__tick.is-first{justify-content:flex-start}.time-strip__tick.is-last{justify-content:flex-end}.time-strip__axis-label{font-size:var(--fig-tiny);color:var(--fig-ink-3);margin:0}.grade>.in-detail{grid-column:1/-1}.grade__whys{gap:var(--space-3);margin:0;display:grid}.grade__whys-row{gap:var(--space-1);display:grid}.grade__whys-row dt{font-weight:600}.grade__whys-row dd{max-inline-size:66ch;margin:0}@media print{.in-detail::details-content{content-visibility:visible;block-size:auto;display:block}.reading-tools,.in-detail__icon,.in-detail__time{display:none}.stop-strip{break-inside:avoid}}@media (forced-colors:active){.stop-strip,.reading-tools__toggle,.in-detail__icon{border:1px solid canvastext}.time-strip__bar{forced-color-adjust:none;background:canvastext}.icon-array__sq.is-on,.verdict[data-verdict=yes] .verdict__box{fill:canvastext}.verdict[data-verdict=yes] .verdict__mark{stroke:canvas}}:root{--fig-ink:var(--text);--fig-ink-2:var(--text-2);--fig-ink-3:var(--text-3);--fig-line:var(--line);--fig-line-strong:var(--line-strong);--fig-accent:var(--cyan);--fig-paper:var(--surface);--fig-tint:var(--surface-2);--fig-alert:var(--alert);--fig-alert-tint:var(--alert-tint);--fig-radius:var(--radius);--fig-small:var(--s--1);--fig-tiny:var(--s--2);--fig-lede:var(--s-1)}.lead__q{color:var(--text-2);font-size:var(--s--1);font-weight:600}.time-strip__tick,.icon-array__count,.key-number__value{font-family:var(--font-mono);font-variant-numeric:tabular-nums}.reading-tools{padding:var(--space-3)var(--space-4);background:var(--surface);border:1px solid var(--line);border-radius:var(--radius)}.reading-tools__text{flex:16rem;max-inline-size:none}.reading-tools__toggle{border-color:var(--line-strong);background:var(--surface-2)}.reading-tools__toggle:hover{border-color:var(--link)}.fig,.key-numbers{padding:var(--space-4);background:var(--surface);border:1px solid var(--line);border-radius:var(--radius)}.key-numbers>.key-number{padding-block-start:var(--space-2)}.icon-array__sq{fill:#0000}.verdict[data-verdict=yes] .verdict__mark{stroke:var(--surface)}:is(.prose,.csec)>:is(.fig:not(.compare),.lead){grid-column:text}:is(.prose,.csec)>.key-numbers{grid-column:wide}@container doc (width>=68rem){.key-numbers--4{grid-template-columns:repeat(4,minmax(0,1fr))}.key-numbers--4 .key-number__value{font-size:2.5rem}}.doc>.stop-strip{grid-column:wide}.stop-strip{border:1px solid color-mix(in srgb,var(--alert)45%,transparent);border-inline-start-width:4px;margin-block-end:var(--space-6)}.stop-strip__title{font-size:var(--s-1)}.stop-strip__list{gap:var(--space-3)var(--space-5)}.stop-strip__text,.stop-strip__call{font-size:var(--s-0)}.stop-strip__links{font-size:var(--s--1)}@media (max-width:29.99rem){.stop-strip{padding:.625rem var(--space-4);margin-block-end:var(--space-5)}.stop-strip__title{margin-block-end:var(--space-2);font-size:1.1875rem}.stop-strip__list{gap:var(--space-2)}.stop-strip__icon .pictogram{block-size:2.25rem;inline-size:2.25rem}.stop-strip__text{font-size:1.0625rem}.stop-strip__foot{margin-block-start:var(--space-2);padding-block-start:var(--space-2)}.stop-strip__call{align-items:flex-start;font-size:1.0625rem}}.fact-sheet{padding:var(--space-3)var(--space-4);background:var(--surface);border:1px solid var(--line);border-radius:var(--radius)}@media (min-width:64rem){.doc>.fact-sheet{padding:var(--space-1)var(--space-4)var(--space-3);margin-block-end:var(--space-6);container:fact-sheet/inline-size}.doc>.fact-sheet .fact-sheet__list{column-gap:var(--space-5);border-block-start:0;grid-template-columns:repeat(2,minmax(0,1fr))}.doc>.fact-sheet .fact-sheet__row{padding-block:var(--space-2);border-block:0;grid-template-columns:minmax(0,1fr);align-content:start;row-gap:.1rem}.doc>.fact-sheet .fact-sheet__row:nth-child(n+3){border-block-start:1px solid var(--line)}.doc>.fact-sheet .fact-sheet__row dd{font-size:1.0625rem;line-height:1.4}.doc>.fact-sheet .fact-sheet__note{margin-block-start:var(--space-1)}}@container fact-sheet (width>=32rem){.doc>.fact-sheet .fact-sheet__list{grid-template-columns:repeat(3,minmax(0,1fr))}.doc>.fact-sheet .fact-sheet__row:nth-child(3){border-block-start:0}}:is(.prose,.csec)>:is(.table-scroll--prose,.compare){grid-column:wide}.table-scroll--prose>table:not(.data-table){inline-size:auto;min-inline-size:min(100%,var(--measure))}.in-detail__body>:is(.table-scroll,.compare,.authorised,.study-table,.reg-table,.mechanism,.explainer,.plate,.diagram,.timeline,.grade-matrix){inline-size:min(100cqi,var(--wide));max-inline-size:none}.compare .table-scroll,.compare .table-scroll>table{margin-block-end:0}.grade .in-detail{margin-block-start:var(--space-4)}.grade__whys-row :is(dt,dd){font-size:var(--s--1)}.grade__whys-row dd{color:var(--text-2)}.grade .in-detail .grade__foot{margin-block-start:var(--space-4)}:is(.prose,.csec)>.product-check{grid-column:wide}.product-check{margin-block:0 var(--space-6);padding:var(--space-5);background:var(--surface);border:1px solid var(--line-strong);border-radius:var(--radius)}.product-check__title{margin:0 0 var(--space-2);font-size:var(--s-1);letter-spacing:-.01em;text-wrap:balance;font-weight:600;line-height:1.3}.product-check__intro{margin:0 0 var(--space-3);max-inline-size:62ch;color:var(--text-2)}.product-check__print{display:none}.product-check__list{gap:0 var(--space-6);grid-template-columns:repeat(auto-fill,minmax(min(100%,26rem),1fr));margin:0;padding:0;list-style:none;display:grid}.product-check__item:is(.product-check__item--extra,[data-check=stop]){grid-column:1/-1}:where(.prose,.csec) li.product-check__item{margin:0}.product-check__item{gap:var(--space-3);max-inline-size:none;padding-block:var(--space-4);border-block-start:1px solid var(--line);grid-template-columns:2.75rem minmax(0,1fr);align-items:start;display:grid}.product-check__icon{--pg-cut:var(--surface-2);background:var(--surface-2);block-size:2.75rem;inline-size:2.75rem;color:var(--text);border-radius:50%;place-items:center;display:grid}.product-check__icon .pictogram{fill:currentColor;block-size:1.75rem;inline-size:1.75rem;display:block}.product-check__check{color:var(--text);margin:0;font-weight:600;line-height:1.35}.product-check__points{margin:var(--space-2)0 0;font-size:var(--s--1);color:var(--text-2);padding-inline-start:1.15em;line-height:1.45}:where(.prose,.csec) .product-check__points li{color:var(--text-2);margin-block:.2rem}.product-check__text{margin:var(--space-1)0 0;font-size:var(--s--1);color:var(--text-2);line-height:1.5}.product-check__emergency{color:var(--text);font-weight:700}.product-check__links{gap:var(--space-1)var(--space-4);margin:var(--space-2)0 0;font-size:var(--s--1);flex-wrap:wrap;font-weight:600;line-height:1.4;display:flex}.product-check__box{display:none}.product-check__item--extra .product-check__icon{--pg-cut:var(--surface);background:var(--surface);box-shadow:inset 0 0 0 2px var(--line-strong)}@media (max-width:29.99rem){.product-check{padding:var(--space-4)}.product-check__item{padding-block:var(--space-3);grid-template-columns:2.25rem minmax(0,1fr)}.product-check__icon{block-size:2.25rem;inline-size:2.25rem}.product-check__icon .pictogram{block-size:1.5rem;inline-size:1.5rem}}@media print{.product-check{break-inside:auto;border:1px solid canvastext}.product-check__print{margin:0 0 var(--space-2);font-size:var(--s--1);display:block}.product-check__item{break-inside:avoid;grid-template-columns:2.25rem minmax(0,1fr) 1.4rem}.product-check__box{border:2px solid canvastext;border-radius:3px;block-size:1.1rem;inline-size:1.1rem;margin-block-start:.15em;display:block}.product-check__links a[href^=\/]:after{content:" (" attr(href)")";font-weight:400}}@media (forced-colors:active){.product-check__icon{border:1px solid canvastext}.product-check__icon .pictogram{fill:canvastext}}:is(.prose,.csec)>.organ-cards{grid-column:wide}.in-detail__body>.organ-cards{inline-size:min(100cqi,var(--wide));max-inline-size:none}.organ-cards{min-inline-size:0;margin-block:var(--space-4)var(--space-7);padding:var(--space-5);border:1px solid var(--line);border-radius:var(--radius);background:var(--surface);container:oc/inline-size}@media (max-width:30rem){.organ-cards{padding:var(--space-3)}}.oc-head{gap:.15rem;margin-block-end:var(--space-4);display:grid}.oc-kicker{font-size:var(--s--2);color:var(--text-2);font-weight:600}.oc-title{font-size:var(--s-1);letter-spacing:-.015em;color:var(--text);text-wrap:balance;font-weight:600;line-height:1.25}.oc-detail{max-inline-size:62ch;font-size:var(--s--1);color:var(--text-2)}.oc-status{border:1.5px dashed var(--line-strong);border-radius:var(--radius-sm);font-size:var(--s--1);color:var(--text);justify-self:start;margin-block-start:var(--space-2);padding:.15rem .65rem;font-weight:600}.oc-sub{margin:0 0 var(--space-3);font-size:var(--s-0);color:var(--text);font-weight:600;line-height:1.3}.oc-cell{padding:var(--space-4);border:1px solid var(--line);border-radius:var(--radius-sm);background:var(--ground)}@media (max-width:30rem){.oc-cell{padding:var(--space-3)var(--space-2)}}.oc-cell__body{gap:var(--space-4);display:grid}@container oc (width>=46rem){.oc-cell__body{align-items:start;gap:var(--space-6);grid-template-columns:max-content minmax(15rem,1fr)}}.oc-diagram{grid-template-columns:minmax(5.75rem,7rem)repeat(var(--oc-n,2),minmax(3.6rem,max(9rem,calc(18rem/var(--oc-n,2)))));row-gap:var(--space-2);max-inline-size:100%;font-size:var(--s--2);color:var(--text-2);grid-template-rows:auto auto 6.5rem auto auto;line-height:1.2;display:grid}.oc-diagram>*{min-inline-size:0;margin:0}.oc-diagram__drug{font-size:var(--s--1);color:var(--text);text-align:center;grid-area:1/2/auto/-1;justify-content:center;align-items:center;gap:.4em;font-weight:600;display:flex}@container oc (width<=24rem){.oc-diagram__drug{grid-column:1/-1}}.oc-diagram__name{color:var(--text);text-align:center;flex-direction:column;grid-row:2;align-items:center;gap:.15rem;padding-inline:.15rem;font-weight:600;display:flex}.oc-diagram__zones{grid-area:3/1;position:relative}.oc-zone{color:var(--text-2);align-items:center;padding-inline-end:var(--space-2);font-weight:500;display:flex;position:absolute;inset-inline:0}.oc-zone[data-zone=out]{block-size:2.25rem;inset-block-start:0}.oc-zone[data-zone=surface]{block-size:1.25rem;color:var(--text);white-space:nowrap;font-weight:600;inset-block-start:2.25rem}.oc-zone[data-zone=in]{block-size:3rem;inset-block-start:3.5rem}.oc-diagram__band{border-block:2px solid var(--line-strong);background:color-mix(in oklch,var(--res-special)18%,var(--ground));grid-area:3/2/auto/-1;align-self:start;block-size:1.25rem;margin-block-start:2.25rem}.oc-dock{grid-row:3;justify-self:center;block-size:6.5rem;inline-size:3.5rem;overflow:visible}.oc-diagram__camp{text-align:center;grid-area:4/1/auto/-1;justify-content:center;align-items:center;gap:.45em;display:flex}.oc-diagram__resp{text-align:center;flex-direction:column;grid-area:5/1/auto/-1;align-items:center;gap:.2rem;display:flex}.oc-diagram__resp>span{border:1px solid var(--line-strong);border-radius:var(--radius-sm);background:var(--surface);color:var(--text);padding:.35rem .7rem;font-weight:500}.oc-glyph{flex:none;overflow:visible}.oc-cell__text{gap:var(--space-3);align-content:start;display:grid}ol.oc-steps{gap:var(--space-2);margin:0;padding:0;list-style:none;display:grid}li.oc-step{gap:var(--space-3);font-size:var(--s--1);color:var(--text);grid-template-columns:auto minmax(0,1fr);margin:0;line-height:1.5;display:grid}.oc-step__n{background:var(--text);block-size:1.6em;inline-size:1.6em;color:var(--ground);font-family:var(--font-mono);font-size:var(--s--2);border-radius:50%;place-items:center;font-weight:700;display:inline-grid}.oc-rec{fill:none;stroke-linecap:round;stroke-linejoin:round}.oc-rec__cup{stroke-width:2.6px}.oc-rec__stem{stroke-width:3.4px}.oc-rec[data-r=glp1]{stroke:var(--res-aromatic)}.oc-rec[data-r=gip]{stroke:var(--res-polar)}.oc-rec[data-r=glucagon]{stroke:var(--res-positive)}.oc-drug{fill:var(--res-hydrophobic);stroke:none}.oc-signal{fill:none;stroke:var(--cyan);stroke-width:2.2px;stroke-linecap:round;stroke-linejoin:round}.oc-signal[data-level=animal],.oc-signal[data-level=in-vitro]{stroke-dasharray:5 3.5;stroke-linecap:butt}.oc-signal[data-level=hypothesis]{stroke:var(--amber);stroke-dasharray:1.5 3.5}.oc-camp{fill:var(--res-negative)}.oc-close{block-size:auto;inline-size:100%;display:block;overflow:visible}.oc-cellbody{fill:var(--surface-2);stroke:var(--text-3);stroke-width:1.4px}.oc-nucleus{fill:color-mix(in oklch,var(--text-3)30%,var(--surface-2));stroke:var(--text-3);stroke-width:1px}.oc-droplet{fill:var(--surface);stroke:var(--line-strong);stroke-width:1px}.oc-fibre{fill:none;stroke:var(--text-3);stroke-width:1.8px;stroke-linecap:round;stroke-linejoin:round}.oc-stripe{stroke:var(--line-strong);stroke-width:1px}.oc-line{flex:none;overflow:visible}.oc-line path{fill:none;stroke:var(--cyan);stroke-width:2.4px}.oc-line path[data-level=animal],.oc-line path[data-level=in-vitro]{stroke-dasharray:7 4}.oc-line path[data-level=hypothesis]{stroke:var(--amber);stroke-dasharray:1 4.5;stroke-linecap:round}.oc-line path[data-level=unknown]{stroke:var(--text-3);stroke-dasharray:1 4.5;stroke-linecap:round}.oc-level{column-gap:var(--space-2);font-size:var(--s--2);color:var(--cyan-text);grid-template-columns:2rem minmax(0,1fr);align-items:start;margin:0;font-weight:600;line-height:1.45;display:grid}.oc-level>.oc-line{margin-block-start:.5em}.oc-level[data-level=hypothesis]{color:var(--amber-text)}.oc-level[data-level=unknown]{color:var(--text-2)}.oc-level--note{color:var(--text-2);font-weight:400}.oc-level--note[data-level]{color:var(--text-2)}.oc-level--note .oc-level__word{color:var(--cyan-text);font-weight:600}.oc-level--note[data-level=hypothesis] .oc-level__word{color:var(--amber-text)}.oc-level--note[data-level=unknown] .oc-level__word{color:var(--text)}.oc-organs{margin-block-start:var(--space-5)}ul.oc-grid{gap:var(--space-4);grid-template-columns:minmax(0,1fr);margin:0;padding:0;list-style:none;display:grid}@container oc (width>=36rem){ul.oc-grid{grid-template-columns:repeat(2,minmax(0,1fr))}}@container oc (width>=54rem){ul.oc-grid{grid-template-columns:repeat(3,minmax(0,1fr))}}li.oc-card{align-content:start;gap:var(--space-2);min-inline-size:0;padding:var(--space-3)var(--space-4)var(--space-4);border:1px solid var(--line);border-inline-start:3px solid var(--cyan);border-radius:var(--radius-sm);background:var(--surface);margin:0;display:grid}li.oc-card[data-level=animal],li.oc-card[data-level=in-vitro]{border-inline-start-style:dashed}li.oc-card[data-level=hypothesis]{border-inline-start-style:dotted;border-inline-start-color:var(--amber)}li.oc-card[data-level=unknown]{border-inline-start-style:dotted;border-inline-start-color:var(--text-3)}.oc-card__name{font-size:var(--s-0);color:var(--text);margin:0;font-weight:600;line-height:1.25}.oc-card__effect{margin:var(--space-1)0 0;color:var(--text);text-wrap:pretty;font-size:1.0625rem;font-weight:500;line-height:1.45}.oc-tile{aspect-ratio:4/3;border-radius:var(--radius-sm);background:var(--oc-ground,var(--surface-2));direction:ltr;position:relative;overflow:hidden}.oc-tile picture{display:block}.oc-tile .oc-tile__pic--light{display:var(--plate-show-light,block)}.oc-tile .oc-tile__pic--dark{display:var(--plate-show-dark,none)}.oc-tile img.oc-tile__img{block-size:auto;max-inline-size:none;display:block;position:absolute}:root[data-scheme=dark] .oc-tile{background:var(--oc-ground-dark,var(--surface-2))}@media (prefers-color-scheme:dark){:root:not([data-scheme=light]) .oc-tile{background:var(--oc-ground-dark,var(--surface-2))}}@media print{:root .oc-tile{background:var(--oc-ground)}:root .oc-tile .oc-tile__pic--light{display:block}:root .oc-tile .oc-tile__pic--dark{display:none}}.oc-card__cell{gap:var(--space-3);padding-block:var(--space-1);grid-template-columns:7rem minmax(0,1fr);align-items:center;display:grid}.oc-card__cellwords{gap:.3rem;min-inline-size:0;display:grid}.oc-card__cellname{font-size:var(--s--1);color:var(--text);font-weight:600;line-height:1.3}ul.oc-chips{flex-wrap:wrap;gap:.2rem .75rem;margin:0;padding:0;list-style:none;display:flex}.oc-chip{font-size:var(--s--2);color:var(--text-2);align-items:center;gap:.3em;margin:0;font-weight:500;line-height:1.3;display:inline-flex}.oc-chip--none{color:var(--text-2);display:block}.oc-legend{align-items:center;gap:.3rem var(--space-4);margin:var(--space-4)0 0;font-size:var(--s--2);color:var(--text-2);flex-wrap:wrap;display:flex}.oc-legend__title{flex-basis:100%;font-weight:600}@container oc (width>=46rem){.oc-legend__title{flex-basis:auto}}.oc-key{grid-template-columns:2rem minmax(0,auto);align-items:start;column-gap:.45em;display:inline-grid}.oc-key>.oc-line{margin-block-start:.45em}.oc-credit{margin:var(--space-2)0 0;font-size:var(--s--2);color:var(--text-2)}.oc-credit__label{font-weight:600}.oc-credit__note{display:block}@media (forced-colors:active){.oc-line path,.oc-signal,.oc-rec{stroke:canvastext}.oc-drug,.oc-camp{fill:canvastext}.oc-diagram__band{border-color:canvastext}}